DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGIRR and Toll-9

DIOPT Version :9

Sequence 1:	XP_005253101.1	Gene:	SIGIRR / 59307	HGNCID:	30575	Length:	504	Species:	Homo sapiens
Sequence 2:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	58/262 - (22%)
Similarity:	107/262 - (40%)	Gaps:	41/262 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    70 VKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLL 134
            :|..|.:...|.....|.|.........|.|:::|..:..|...  |:.|.||:.||:.  |.:|
  Fly   644 LKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHV--TNTVIAVMGSLVG--ACIL 704

Human   135 AALLYVKCRLNVLLWYQ----------------DAYGEVEIND-GKLYDAYVSYSDCPEDRKFVN 182
            ..::|:| |.::..:|.                :.:..:...| ..:||.::||  |..||.:|.
  Fly   705 GFIIYLK-RWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISY--CQNDRTWVL 766

Human   183 FILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCR----RLIVVLSDAFLSRAWCSHSFR 243
            ..|.|.:|......:.|.:||.    :....:|.|:..|.    .|::::|..||...||.....
  Fly   767 NELLPNVEETGDVSICLHERDF----QIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMY 827

Human   244 EGLCRLLELTRRPIFITF---EGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQL 305
            ....|:.|:::..:.:.|   ..:|:.|     :.|:....:.|.:.| |.:......|||.::.
  Fly   828 LAQHRIFEVSKEHLILVFLEDIPRRKRP-----KTLQYLMDVKTYIKW-PTAKEDRKLFWKRLKR 886

Human   306 AL 307
            :|
  Fly   887 SL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGIRR	XP_005253101.1	Ig	8..111	CDD:299845	8/40 (20%)
SIGIRR	XP_005253101.1	TIR	165..311	CDD:279864	36/150 (24%)
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566
		leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..356	CDD:275380
		LRR_8	<344..387	CDD:290566
		leucine-rich repeat	357..381	CDD:275380
		leucine-rich repeat	382..397	CDD:275380
		leucine-rich repeat	405..430	CDD:275380
		LRR_8	431..488	CDD:290566
		leucine-rich repeat	432..453	CDD:275380
		LRR_RI	<449..536	CDD:238064
		leucine-rich repeat	454..477	CDD:275380
		LRR_8	477..536	CDD:290566
		leucine-rich repeat	478..501	CDD:275380
		leucine-rich repeat	502..525	CDD:275380
		TIR	751..891	CDD:214587	36/150 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910