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Protein Alignment SIGIRR and Toll-7

DIOPT Version :9

Sequence 1:	XP_005253101.1	Gene:	SIGIRR / 59307	HGNCID:	30575	Length:	504	Species:	Homo sapiens
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	442	Identity:	108/442 - (24%)
Similarity:	169/442 - (38%)	Gaps:	96/442 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   110 LQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEI------NDGKLYDAY 168
            ||...|.|::..:.|:|.:|..|::.|:::. .|.::.:|....|| |.:      ...|||||.
  Fly  1039 LQHGIPESYIPLLAAALALLFLLVVIAMVFA-FRESLRIWLFAHYG-VRVFGPRCEESEKLYDAV 1101

Human   169 VSYSDCPEDRKFVNFILKPQLER-RRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAF 232
            :.:|  .:|.:||...|..|||. |...::.|..|||...| ....||......||::::|:..|
  Fly  1102 LLHS--AKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDA-THYQLLEATRVSRRVVILLTRNF 1163

Human   233 LSRAW--CS-----HSFREGLCRLLELTRRPIFITFEGQRRDPAHPAL------RLLRQHRHLVT 284
            |...|  |.     |....|..:.|.:...| .:.||.:......|.|      |:.|..||
  Fly  1164 LQTEWARCELRRSVHDALRGRPQKLVIIEEP-EVAFEAESDIELLPYLKTSAVHRIRRSDRH--- 1224

Human   285 LLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQT---------QLQDDKDPMLILR----- 335
                          ||::::.|||  |.|....|:..|         :::....|.|:.|
  Fly  1225 --------------FWEKLRYALP--VDYPTFRGNNYTLELDHHNHERVKQPASPGLLYRQAPPP 1273

Human   336 -----------GRVPEGRALDSEVDPDPEGDLGMPAQPHSPTGEAQHRAEWGQAQGTGPGGAPGV 389
                       |.||:...:::.|..:........|.| ||  ..|.|   |:..|:|.||
  Fly  1274 AYCGPADAVGIGAVPQVVPVNASVPAEQNYSTATTATP-SP--RPQRR---GEQPGSGSGG---- 1328

Human   390 EDSSRHRE--PLHGLCPGGARPSVCLGTSWASQAITAGGEQ------GQP--LAVGLGQGC-GWP 443
             :...|.:  ..||:.|    ||..:.:|..|...|...||      |.|  ||:...|.. .|.
  Fly  1329 -NHHLHAQYYQHHGMRP----PSEHIYSSIDSDYSTLDNEQHMLMMPGAPGGLAMEAAQRAQTWR 1388

Human   444 PQASRSPHPRCPGACLWRAISSTAHQWGLAGREPEQRSGRLGSRLAKLQCPH 495
            |:..:....:.....|....|..|||.....::.:|:.....:...:.|.||
  Fly  1389 PKREQLHLQQAQAGTLGSKASQAAHQQQQQQQQQQQQQPNPTAVSGQQQGPH 1440

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.