DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SIGIRR and Tehao

DIOPT Version :9

Sequence 1:XP_005253101.1 Gene:SIGIRR / 59307 HGNCID:30575 Length:504 Species:Homo sapiens
Sequence 2:NP_001285901.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster


Alignment Length:378 Identity:85/378 - (22%)
Similarity:140/378 - (37%) Gaps:117/378 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    32 CTAWVVSG-----PHCSLPSVQWLKDGLP--------LGIGGHY-----SLHEYSWVKANLSEVL 78
            |..||...     ..|...|::.|.| ||        |.:|.:.     ::.|:|.. ||:|.:.
  Fly   425 CICWVQRSVGSLIVDCRGTSLEELPD-LPRTTLLSTVLKVGNNSLTSLPTVSEHSGY-ANVSGLF 487

Human    79 VS----SVLGV------NVTSTEVYG----------------------------AFTCSIQNISF 105
            :|    :.||.      |:|..:|.|                            ..||..:::|.
  Fly   488 LSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSL 552

Human   106 SSFTLQRAGPTSHVAAVLA-----------------SLLVLLALLLAALLYVKCRL--------- 144
            ..|..........:|.::.                 |.::|::.::..|:.|.|.|         
  Fly   553 LFFVRTNPQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQ 617

Human   145 ---------NVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLER-RRGYKLFL 199
                     |:.||:   ..|.|::..|.|||::|||.  :|.:.::.:| |:||. ...::|.|
  Fly   618 ELKIWLYNNNLCLWW---VSEEELDKDKTYDAFISYSH--KDEELISKLL-PKLESGPHPFRLCL 676

Human   200 DDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQ 264
            .|||.|........::..:...:|:|:|||..|:...|....||......|:..|:.|.|..   
  Fly   677 HDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIIL--- 738

Human   265 RRDPAH--PALRLLRQHRHLVTLLLWRPGSVTPSSD--FWKEVQLALP--RKV 311
            .|:..|  .....||.:..|.|.|.|        .|  ||.::..|:|  |:|
  Fly   739 YRELEHMNGIDSELRAYLKLNTYLKW--------GDPLFWSKLYYAMPHNRRV 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIGIRRXP_005253101.1 Ig 8..111 CDD:299845 27/134 (20%)
TIR 165..311 CDD:279864 44/152 (29%)
TehaoNP_001285901.1 leucine-rich repeat 185..207 CDD:275380
leucine-rich repeat 209..232 CDD:275380
leucine-rich repeat 233..261 CDD:275380
LRR_RI <261..370 CDD:238064
leucine-rich repeat 262..284 CDD:275380
leucine-rich repeat 285..309 CDD:275380
LRR_8 309..368 CDD:290566
leucine-rich repeat 310..333 CDD:275380
leucine-rich repeat 334..357 CDD:275380
leucine-rich repeat 358..381 CDD:275380
leucine-rich repeat 445..482 CDD:275380 8/38 (21%)
LRR_8 459..516 CDD:290566 14/57 (25%)
leucine-rich repeat 483..505 CDD:275380 4/21 (19%)
LRR_4 486..521 CDD:289563 7/34 (21%)
TIR 643..779 CDD:214587 42/149 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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