Protein Alignment RBBP5 and rbbp-5

DIOPT Version :10

• Sequence 1: XP_047282850.1
• Gene: RBBP5 / 5929
• HGNCID: 9888
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_495222.2
• Gene: rbbp-5 / 174019
• WormBaseID: WBGene00017683
• Length: 454
• Species: Caenorhabditis elegans
• Alignment Length: 422
• Identity: 179/422 - (42%)
• Similarity: 251/422 - (59%)
• Gaps: 22/422 - (5%)

Human    43 SFGQNYPEEADGTLDC-ISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCS 106
            ::|..:|||.:..||. .:.|..|.|||||:::||||.|||::|:||:||.||:..|||..||..
 Worm     8 TYGAQFPEELECHLDLQNASANCCKFNRWGSIVAVGCTDGRVLIYDFMTRNIARTFSAHCLPVSC 72

Human   107 LCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLT 171
            |.|||||.||:::|.||.::.:|||:|....|.||.|.:....:|||:.||.:|..:...|.:..
 Worm    73 LSWSRDGRKLLTSSADNSIAMFDVLAGTLLHRIRFNSMVTFAMFHPRNDNKAIVLQVNKQPTVEQ 137

Human   172 LSDSKHVVL----PVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSN 232
            .|.....||    |...|...:.| |:||:|:||..|..|||:|:...::...||..:..|
 Worm   138 FSPRIQTVLANDTPGSSDESASCV-SYDRKGKYIIAGTGKGKLLIYNAETLKCVAWCKQNT---- 197

Human   233 TTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGD 297
            ...|:.|....|....:.||.||:||.|:..::|. .|....|...|:.|:||:..||..|...|
 Worm   198 VQQIRQIIVPMKSRFIITNTQDRVIRTYELEDLLH-QRGQMVEAKYKVLDMVNKAAWKNVCTDSD 261

Human   298 GEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVE 362
            |.|:...|.:.|:|||||.:.|:|:|||||.:||.||||.|||.||||.||:.|.||:|.|..||
 Worm   262 GLYVCGASTKAHSLYIWESNTGSLIKILHGNKGEALLDVQWHPTRPIILSIAQGTVSMWTQAHVE 326

Human   363 NWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEE 427
            |||||||:|:||:||.:|.|:|:|||:||||..|...:.:..|||:.:||.:|.|.....|||||
 Worm   327 NWSAFAPEFQELEENEKYIEKENEFDMEDEDADEDMTSKSQDAEDDIIDVVNVRPEDYLASSDEE 391

Human   428 ----------LEDSKALLYLPIAPEVEDPEEN 449
                      || |..|.|:|:..::|:.:.:
 Worm   392 DCNIMKPARNLE-SGPLWYIPVPLDIENADND 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBBP5	XP_047282850.1	WD40 repeat	64..99	CDD:293791	20/34 (59%)
		WD40	<66..356	CDD:441893	125/293 (43%)
		WD40 repeat	105..141	CDD:293791	16/35 (46%)
		WD40 repeat	146..181	CDD:293791	10/38 (26%)
		WD40 repeat	189..225	CDD:293791	14/35 (40%)
		WD40 repeat	236..281	CDD:293791	14/44 (32%)
		WD40 repeat	289..326	CDD:293791	17/36 (47%)
		WD40 repeat	333..356	CDD:293791	16/22 (73%)
rbbp-5	NP_495222.2	WD40	17..320	CDD:475233	129/308 (42%)
		WD40 repeat	30..65	CDD:293791	20/34 (59%)
		WD40 repeat	107..151	CDD:293791	12/43 (28%)
		WD40 repeat	159..194	CDD:293791	14/35 (40%)
		WD40 repeat	201..246	CDD:293791	14/45 (31%)
		WD40 repeat	254..290	CDD:293791	16/35 (46%)