Protein Alignment RBBP4 and Caf1-55

DIOPT Version :10

• Sequence 1: NP_005601.1
• Gene: RBBP4 / 5928
• HGNCID: 9887
• Length: 425
• Species: Homo sapiens
• Sequence 2: NP_524354.1
• Gene: Caf1-55 / 41836
• FlyBaseID: FBgn0263979
• Length: 430
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 378/419 - (90%)
• Similarity: 403/419 - (96%)
• Gaps: 4/419 - (0%)

Human     1 MADKE----AAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDF 61
            |.|:.    .:|||||||||||||||||||||||||||||||||||||||||||||||:.:|||:
  Fly     1 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDY 65

Human    62 SIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 126
            |:|||:||||||||||||:|||||||::|||||.||||:|||||||||||.||||||||||||||
  Fly    66 SVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGE 130

Human   127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSG 191
            ||||||||||.|:||||||||||||||||||||||:|||||.|||||||||||||||||||||:|
  Fly   131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG 195

Human   192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD 256
            :|||||||||||||||:|.|||.:|:|||.||||||||||||:||||||||||||||||||||||
  Fly   196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWD 260

Human   257 TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 321
            ||:||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   261 TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 325

Human   322 QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386
            |||||||||||||||||||||:||||||||||||.||||||||||||||||||||||||||||||
  Fly   326 QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390

Human   387 PWVICSVSEDNIMQVWQMAENIYNDEDPE 415
            ||:||||||||||||||||||:||||:||
  Fly   391 PWIICSVSEDNIMQVWQMAENVYNDEEPE 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBBP4	NP_005601.1	Interaction with ARMC12. /evidence=ECO:0000269|PubMed:30026490	2..132		112/133 (84%)
		CAF1C_H4-bd	19..88	CDD:463513	61/68 (90%)
		WD40	122..403	CDD:475233	262/280 (94%)
		WD 2. /evidence=ECO:0000269|PubMed:39460621, ECO:0007744|PDB:8TX8	126..175		44/48 (92%)
		WD40 repeat	128..175	CDD:293791	42/46 (91%)
		WD 3. /evidence=ECO:0000269|PubMed:39460621, ECO:0007744|PDB:8TX8	176..223		38/46 (83%)
		WD40 repeat	180..224	CDD:293791	35/43 (81%)
		WD 4. /evidence=ECO:0000269|PubMed:39460621, ECO:0007744|PDB:8TX8	225..270		41/44 (93%)
		WD40 repeat	231..270	CDD:293791	35/38 (92%)
		WD 5. /evidence=ECO:0000269|PubMed:39460621, ECO:0007744|PDB:8TX8	271..314		42/42 (100%)
		WD40 repeat	276..314	CDD:293791	37/37 (100%)
		WD 6. /evidence=ECO:0000269|PubMed:39460621, ECO:0007744|PDB:8TX8	315..371		53/55 (96%)
		WD40 repeat	320..371	CDD:293791	48/50 (96%)
		WD 7. /evidence=ECO:0000269|PubMed:39460621, ECO:0007744|PDB:8TX8	372..404		30/31 (97%)
		WD40 repeat	377..402	CDD:293791	23/24 (96%)
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:463513	61/68 (90%)
		WD40 repeat	132..179	CDD:293791	42/46 (91%)
		WD40	<176..409	CDD:441893	218/232 (94%)
		WD40 repeat	184..228	CDD:293791	35/43 (81%)
		WD40 repeat	235..274	CDD:293791	35/38 (92%)
		WD40 repeat	280..318	CDD:293791	37/37 (100%)
		WD40 repeat	324..375	CDD:293791	48/50 (96%)
		WD40 repeat	381..406	CDD:293791	23/24 (96%)