Protein Alignment ACE2 and ace2

DIOPT Version :10

• Sequence 1: NP_068576.1
• Gene: ACE2 / 59272
• HGNCID: 13557
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_001007298.2
• Gene: ace2 / 492331
• ZFINID: ZDB-GENE-041114-6
• Length: 818
• Species: Danio rerio
• Alignment Length: 815
• Identity: 470/815 - (57%)
• Similarity: 587/815 - (72%)
• Gaps: 23/815 - (2%)

Human     6 WLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWS 70
            ||||..:|..|...|:|::|:.||:||:.||.|:.||.:||||.|||:|::||......|...||
Zfish     5 WLLLLALASVACCQTVEDRAREFLNKFDEEASDIMYQYTLASWAYNTDISQENADKEAEAYAIWS 69

Human    71 AFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNP 135
            .:..:.|..:..||:.:|.:..:|:|||.||..||..||.||:..|..|::.|||||:|..||..
Zfish    70 EYYNKMSEESNAYPIDQISDPIIKMQLQKLQDKGSGALSPDKASELRNIMSEMSTIYNTATVCKI 134

Human   136 DNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYG 200
            |:|.:|..|||||..|||.|.||:|||..||.||...|.::|||||:||.||||.|:.|:|||:|
Zfish   135 DDPTDCQTLEPGLESIMAESRDYDERLHVWEGWRVATGMKMRPLYEKYVDLKNEAAKLNNYEDHG 199

Human   201 DYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAH 265
            ||||||||......|.|||.|:|||....::||.|||:.|||||||||.:.||.:|....|||||
Zfish   200 DYWRGDYETIDDPKYSYSRDQVIEDARRIYKEILPLYKELHAYVRAKLQDVYPGHIGSDACLPAH 264

Human   266 LLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330
            ||||||||||||||.|.:|:..:|:|||:.|||:|.||..|:||||||||:||.:|.|...||.|
Zfish   265 LLGDMWGRFWTNLYPLMIPYPDRPDIDVSSAMVEQGWDEIRLFKEAEKFFMSVNMPAMFDNFWNN 329

Human   331 SMLTDPGNVQKAVCHPTAWDLG-KGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRN 394
            ||...| ..:..||||||||:| :.||||.|||||.||||||.||||||.||.|||...|:|||:
Zfish   330 SMFIKP-EERDVVCHPTAWDMGNRKDFRIKMCTKVNMDDFLTVHHEMGHNQYQMAYRNHPYLLRD 393

Human   395 GANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKW 459
            |||||||||||||||||||||.||:|:|||..||::|.||:||||||||||||||||||||||:|
Zfish   394 GANEGFHEAVGEIMSLSAATPSHLQSLGLLPSDFKQDYETDINFLLKQALTIVGTLPFTYMLEEW 458

Human   460 RWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQ 524
            ||.|||.:||||:||::||:||||:|||.|.||.|||||||.:|||||.|||||||:|||:||||
Zfish   459 RWQVFKAKIPKDEWMQQWWQMKRELVGVAEAVPRDETYCDPPALFHVSGDYSFIRYFTRTIYQFQ 523

Human   525 FQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFE 589
            ||||||:||.|.|||:||||:|||:||.||.:||.||:|..||.|||.|.|...|:.:|||:||.
Zfish   524 FQEALCKAAGHTGPLYKCDITNSTKAGDKLRHMLELGRSMSWTRALEEVAGTTKMDSQPLLHYFS 588

Human   590 PLFTWLKDQN-KNSFV-GWSTDWSP------------YADQSIKVRISLKSALGDKAYEWNDNEM 640
            .|..|||::| ||:.| ||:.:.:|            .::.:.|||||||||||::||.||.|::
Zfish   589 TLMEWLKEENQKNNRVPGWNVNVNPGVLTSSFINDAEISENAFKVRISLKSALGNEAYTWNANDI 653

Human   641 YLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIR 705
            |||:|::|:|||||:||.||..:.|..|::...|...||||.|.|..|.....:||:.|||.||.
Zfish   654 YLFKSTMAFAMRQYYLKEKNTDVNFTPENIHTYNETARISFKFAVMDPTKTGTVIPKAEVENAIW 718

Human   706 MSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKK 770
            ..|.|||.||.|:|.:|||:|:..||.||.:..::|||:||||||||.|:..:.|:.|||.:|||
Zfish   719 QERDRINGAFLLSDETLEFVGLMATLAPPKEEKITIWLVVFGVVMGVTVLAGIYLVTTGILNRKK 783

Human   771 K-NKAR--SGENPYASIDISKGENNPGFQNTDDVQ 802
            | .||:  |.||||...|  .||.|..|:  :|::
Zfish   784 KAKKAKEASVENPYDGSD--DGEVNKAFE--EDIE 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE2	NP_068576.1	Peptidase_M2	19..606	CDD:460196	365/589 (62%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	30..41		5/10 (50%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	82..84		0/1 (0%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	353..357		1/3 (33%)
		Collectrin	617..770	CDD:465322	80/152 (53%)
		Essential for cleavage by ADAM17. /evidence=ECO:0000269|PubMed:24227843	652..659		5/6 (83%)
		Essential for cleavage by TMPRSS11D and TMPRSS2. /evidence=ECO:0000269|PubMed:24227843	697..716		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..805		13/33 (39%)
		LIR. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	778..786		4/7 (57%)
		SH2-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..785		1/3 (33%)
		Endocytic sorting signal. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..784		1/2 (50%)
		PTB. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	792..795		1/2 (50%)
		PDZ-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	803..805		470/815 (58%)
ace2	NP_001007298.2	None