Protein Alignment ACE2 and Ance-3

DIOPT Version :10

• Sequence 1: NP_068576.1
• Gene: ACE2 / 59272
• HGNCID: 13557
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_001033904.1
• Gene: Ance-3 / 34808
• FlyBaseID: FBgn0032536
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 201/633 - (31%)
• Similarity: 322/633 - (50%)
• Gaps: 56/633 - (8%)

Human    30 DKFN---------HEAEDLFYQSSL-----------------------ASWNYNTNITEENVQNM 62
            |:||         ...:|..||..|                       |.||:.||:.:......
  Fly   186 DRFNLNQGYLERQRYQQDRRYQQELEKLRILLVESDQKGSLECTANVAAQWNFETNVNDFTQTEA 250

Human    63 NNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIY 127
            .||..::..|.:..:..::......|.:..:..||....:.|.:.|..|...|.|.:||.|..:|
  Fly   251 LNAQQRYVEFQRITAEQSKRINKDLIFDRRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEMLFLY 315

Human   128 STGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMA 191
            ::.::|....|.:| |...|.|.:|||.|.|::|....|..:..:.|:.:|..||:.:.:..|:|
  Fly   316 NSAEICAYQQPFQCDLHYIPQLKDIMAKSRDWDELQHTWVEYHRKAGRGMRDSYEQLIDVMQEVA 380

Human   192 RANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSY 255
            ..|:..:.|:||...||          .|...:|::..:|:|:||||.||||||.||.:.| |..
  Fly   381 YVNNVTNGGEYWYLAYE----------SGNFRQDMDIVWEQIRPLYEGLHAYVRRKLRDYYGPDR 435

Human   256 ISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGL 320
            |:.|..:|:|:||:|:|:.|:|:..:.:|:..:..||||..||:|.:..|.:|:.||:||.|:.:
  Fly   436 INRIAPIPSHILGNMYGQSWSNVLDILIPYPGRKLIDVTPRMVEQGYTPQLMFQLAEEFFTSINM 500

Human   321 PNMTQGFWENSMLTDPGNVQKAVCHPTAWDL-GKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMA 384
            ..:...|:.||:...|.: ::.:|.|:|||. .:.|||:.:||.:.....::.||||.||||.:.
  Fly   501 SAVGPEFYRNSIFEQPLD-RRVLCEPSAWDFCNRHDFRVKICTDINQRSLISVHHEMAHIQYFLQ 564

Human   385 YAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGT 449
            |...|.:.|||||..||:|||:.:.||.:||:||:::|||.....| :..:||:|...|:..|..
  Fly   565 YRHLPKIFRNGANPAFHQAVGDAIGLSVSTPRHLQTLGLLQRSLDE-SSYDINYLFTMAIDKVAF 628

Human   450 LPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIR 514
            |||...|:.||:.||.|...|......:|.::.:..|:..||...|...||.:.:|:..:..:|:
  Fly   629 LPFALSLDNWRYDVFSGNANKRTMNCHYWNLREKYSGIKPPVLRSEKDFDPGAKYHIPANIPYIK 693

Human   515 YYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENV 573
            |:..|:.|||....||:.:..      ..|||:|||.....||..|..::..|.|:||...||..
  Fly   694 YFFSTVLQFQIYRGLCRESGQYVPGDPRKPLHQCDIYRQPAAGNILKTLMSKGASQPWQEVLEET 758

Human   574 VGAKNMNVRPLLNYFEPLFTWLKDQN--KNSFVGWSTDWSPYADQSIK 619
            :....::...|..||.||..||:.:|  .|.:|||:.| ..|..:||:
  Fly   759 LREGRLDGTALREYFAPLEEWLRQENLRTNEYVGWNYD-GDYCKRSIE 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE2	NP_068576.1	Peptidase_M2	19..606	CDD:460196	195/618 (32%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	30..41		4/19 (21%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	82..84		0/1 (0%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	353..357		1/3 (33%)
		Collectrin	617..770	CDD:465322	2/3 (67%)
		Essential for cleavage by ADAM17. /evidence=ECO:0000269|PubMed:24227843	652..659
		Essential for cleavage by TMPRSS11D and TMPRSS2. /evidence=ECO:0000269|PubMed:24227843	697..716
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..805
		LIR. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	778..786
		SH2-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..785
		Endocytic sorting signal. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..784
		PTB. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	792..795
		PDZ-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	803..805
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:341055	185/579 (32%)