Protein Alignment ACE2 and Ance

DIOPT Version :10

• Sequence 1: NP_068576.1
• Gene: ACE2 / 59272
• HGNCID: 13557
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_477046.1
• Gene: Ance / 34805
• FlyBaseID: FBgn0012037
• Length: 615
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 223/612 - (36%)
• Similarity: 345/612 - (56%)
• Gaps: 22/612 - (3%)

Human     8 LLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAF 72
            ||:.:|||.|....|.|||.:|:..|.|........:.|:|.|.:|||:||.:..|....:.:.|
  Fly     8 LLATLAVTQALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKF 72

Human    73 LKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN 137
            :||.::....:..:..|:..:|.|.:||.:.|.:.|.||....|...|:.|.:.::..|||:..:
  Fly    73 MKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKD 137

Human   138 PQEC-LLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGD 201
            ..:| |.|:|.:.|:::.|.|:.|..:.|..:..:.|..:|..:|.||.|..:.|:.|::....:
  Fly   138 STKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAE 202

Human   202 YWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAH 265
            .|..:||       |.:..|.:||:   |.:|:|||:.:|.|||.:|...| .:.:|..|.:|.|
  Fly   203 AWLDEYE-------DDTFEQQLEDI---FADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMH 257

Human   266 LLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330
            |||:||.:.|:.:..:..||.:||.:||:..|..|.:...::|:..:.||.|:.|..:.|.||:.
  Fly   258 LLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDK 322

Human   331 SMLTDPGNVQKAVCHPTAWDLG-KGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRN 394
            |::..|.:.:..|||.:|||.. ..|.||..||:||.|...|.|||:|||||.:.|..|||:.|.
  Fly   323 SIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRT 387

Human   395 GANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKW 459
            |||.|||||||:::|||.:|||||:.||||. |:..|:|..||.|...||..:..|||.:.::|:
  Fly   388 GANPGFHEAVGDVLSLSVSTPKHLEKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKY 451

Human   460 RWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQ 524
            ||.:|:||:.|..|...:|:::.|..|:..||...|...|..:.:|:|.|..::||....:.|||
  Fly   452 RWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQ 516

Human   525 FQEALC-QAAKH-----EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRP 583
            |.::.| :|.::     |.||..|||..|..||....|||.:|.|:||..|||...|.:.|:.:.
  Fly   517 FYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKA 581

Human   584 LLNYFEPLFTWLKDQN--KNSFVGWST 608
            :..|||||..||:.:|  .|..:||:|
  Fly   582 IAEYFEPLRVWLEAENIKNNVHIGWTT 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE2	NP_068576.1	Peptidase_M2	19..606	CDD:460196	214/597 (36%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	30..41		2/10 (20%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	82..84		0/1 (0%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	353..357		1/3 (33%)
		Collectrin	617..770	CDD:465322
		Essential for cleavage by ADAM17. /evidence=ECO:0000269|PubMed:24227843	652..659
		Essential for cleavage by TMPRSS11D and TMPRSS2. /evidence=ECO:0000269|PubMed:24227843	697..716
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..805
		LIR. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	778..786
		SH2-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..785
		Endocytic sorting signal. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..784
		PTB. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	792..795
		PDZ-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	803..805
Ance	NP_477046.1	Peptidase_M2	19..606	CDD:460196	214/597 (36%)