Protein Alignment ACE2 and Acer

DIOPT Version :10

• Sequence 1: NP_068576.1
• Gene: ACE2 / 59272
• HGNCID: 13557
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_477195.1
• Gene: Acer / 34189
• FlyBaseID: FBgn0016122
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 219/616 - (35%)
• Similarity: 331/616 - (53%)
• Gaps: 24/616 - (3%)

Human     6 WLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWS 70
            ||...|....:..:::.| |:.|.:..|.:....|::..|:.:|||||:||.|.|.|.....:.:
  Fly    16 WLPHGLSMGNSCSASVLE-ARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNA 79

Human    71 AFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNP 135
            ...|..:...:.....:.::..::.|.:.|.:.|:|.|:.|....|...:::|.|.|:|..||:.
  Fly    80 ELNKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCSY 144

Human   136 DNPQEC-LLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDY 199
            .|..:| |.|||.:.|.:::|.|..|..|.|..|..:.|..:|..:.|||.|..:.::.|.:..|
  Fly   145 TNRSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSY 209

Human   200 GDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLP 263
            .|||...||     ..|:.|     .::.||:::.|.|..||.|||.:|...| |..:...|.:|
  Fly   210 ADYWVQFYE-----DPDFER-----QLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIP 264

Human   264 AHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFW 328
            ..|||:|||:.|..|..|..|:.:||.:||...|..|.:..|::|:..::||.|:|:..:...||
  Fly   265 ISLLGNMWGQSWNELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFW 329

Human   329 ENSMLTDPGNVQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLL 392
            ..|:||.|.: :..|||.:|||..: .|.||.|||:|....|...|||:|||||.:.|..||.:.
  Fly   330 NLSVLTRPDD-RHVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVY 393

Human   393 RNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLE 457
            |...|.|||||||::::||..:.||||:|||:. :.:.|.::.||.|.||||:.:..|||.|.::
  Fly   394 RGAPNPGFHEAVGDVIALSVMSAKHLKAIGLIE-NGRLDEKSRINQLFKQALSKIVFLPFGYAVD 457

Human   458 KWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQ 522
            |:|:.||:.|:.:.||...:|:|:.|..||..||...|...||.:.:|:..|..::||:...::|
  Fly   458 KYRYAVFRNELDESQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQ 522

Human   523 FQFQEALCQAAKHEGP------LHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNV 581
            |||.:|||:.|....|      |..|||..|..||:.|...|..|.|..|...||...|...|:.
  Fly   523 FQFHKALCRKAGQYAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDP 587

Human   582 RPLLNYFEPLFTWLKDQNKNSFVGWSTDWSP 612
            ..||.|||||:.|||.:  ||.:|....|.|
  Fly   588 AALLEYFEPLYQWLKQE--NSRLGVPLGWGP 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE2	NP_068576.1	Peptidase_M2	19..606	CDD:460196	213/595 (36%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	30..41		1/10 (10%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	82..84		0/1 (0%)
		Interaction with SARS-CoV spike glycoprotein. /evidence=ECO:0000269|PubMed:15791205	353..357		1/4 (25%)
		Collectrin	617..770	CDD:465322
		Essential for cleavage by ADAM17. /evidence=ECO:0000269|PubMed:24227843	652..659
		Essential for cleavage by TMPRSS11D and TMPRSS2. /evidence=ECO:0000269|PubMed:24227843	697..716
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..805
		LIR. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	778..786
		SH2-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..785
		Endocytic sorting signal. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	781..784
		PTB. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	792..795
		PDZ-binding. /evidence=ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498	803..805
Acer	NP_477195.1	Peptidase_M2	33..614	CDD:460196	214/595 (36%)