Protein Alignment KDM5A and JHD2

DIOPT Version :10

• Sequence 1: NP_001036068.1
• Gene: KDM5A / 5927
• HGNCID: 9886
• Length: 1690
• Species: Homo sapiens
• Sequence 2: NP_012653.1
• Gene: JHD2 / 853583
• SGDID: S000003880
• Length: 728
• Species: Saccharomyces cerevisiae
• Alignment Length: 746
• Identity: 200/746 - (26%)
• Similarity: 320/746 - (42%)
• Gaps: 185/746 - (24%)

Human    18 ECPVFEPSWEEFTDPLSFIG--RIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNEL 80
            |.|...|:.:||.:|:.::.  .|:.|..:.|:.|:.||..:.||.:.::::|.|.||:|.|..|
Yeast     3 EIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPPLSIDMENFTFQPRIQNLENL 67

Human    81 EAMTRVRLDFLDQLAKF------------------WELQGSTLKIPVVERKILDLYALSKIVASK 127
            :...|.||.|:.||..|                  .|...||....::::|:......|:::...
Yeast    68 DLKNRCRLFFMKQLNNFKRSVKDPSKLILREPYTIVEYSDSTHASEILKKKVYFYDVFSELIKDN 132

Human   128 GGFEMVTKEKK-----------------WSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSG 175
            ......|:..:                 |..:..:.....|     |||..:|:.:..|.:|..
Yeast   133 RTLTDTTQSFRRKLKFRDISQLRGDISLWRTISKKFNVPIG-----LLKEIFEKYIASYYIFLH- 191

Human   176 VSLMGVQMPNLDLKEKVE--------PEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSR 232
                       .|.|.|.        |:.|.:|.:...:.|...|
Yeast   192 -----------SLNENVHTALHADQYPKSLLSDDEDDFDLGPDSN-------------------- 225

Human   233 NTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCM 297
                                .|:..:||:          .||                     |:
Yeast   226 --------------------SGSDFEEDD----------DDA---------------------CI 239

Human   298 FCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVREYT 362
            .|.:.|:..:.:|||.||..:|.:||.|||..||.|||.|..|:.     ....:||.|...:|:
Yeast   240 VCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIV-----GNGYYGFTQDTHDYS 299

Human   363 LQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVI--VEYGADISSKDFG--SGFP 423
            |..|.|......|..  :|...:..:.:|:.||.||:......:  |:|||||.::..|  :|||
Yeast   300 LPEFQEYCKRQNSRL--LPARKLSIDELEEMFWSLVTKNRRSSLTTVKYGADIHNELPGQITGFP 362

Human   424 VKDGRRKILPEEE-----EYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWH 483
            .::...|.:..:|     :|.....||.|:|:...|:|.....:||||.:||:|:|..||:||||
Yeast   363 TREFIPKNINGDELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWH 427

Human   484 IEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM---NPNVL 545
            :||.::.|.||.|.|:||.||.:|.....:..:::.:::|:||..||||||||||::   :|| .
Yeast   428 MEDQYTLSANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLISPYDPN-F 491

Human   546 MEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCV 610
            .:.|:|||:..|...|:::|||:.||:|||.||||.|||||....|||.|...:..|:..::.||
Yeast   492 KKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDYKLTQKACV 556

Human   611 F-------------SHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLR--ESVVQMGVLM 660
            |             :.:.|:|..|...:|..        ..:.....|..|:|  :::|....|:
Yeast   557 FDMFDLMINVLDKYNKDTLLFNDAFVRQCYS--------SLIVFYNTELKRIRKIQAIVPRTTLL 613

Human   661 SEEEVFELVPDDERQ-----CSACRTTCFLS 686
               || ...|:||.:     ||.|:|.|.::
Yeast   614 ---EV-HTDPNDEDEEYDIFCSQCKTICSIA 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM5A	NP_001036068.1	JmjN	18..59	CDD:128818	12/42 (29%)
		ARID_KDM5A	84..175	CDD:350637	21/125 (17%)
		PHD1_KDM5A	295..343	CDD:277075	21/47 (45%)
		GSGFP motif. /evidence=ECO:0000250|UniProtKB:Q3UXZ9	419..423		2/5 (40%)
		JmjC	470..586	CDD:396791	57/118 (48%)
		zf-C5HC2	676..728	CDD:460750	5/11 (45%)
		PLU-1	741..1072	CDD:462475
		PHD2_KDM5A	1163..1215	CDD:277079
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1327..1348
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1407..1433
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1509
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1516..1543
		PHD3_KDM5A	1608..1659	CDD:277156
		Interaction with LMO2. /evidence=ECO:0000269|PubMed:9129143	1623..1690
JHD2	NP_012653.1	JmjN	3..46	CDD:128818	12/42 (29%)
		PHD_BAZ1A_like	237..282	CDD:277019	21/65 (32%)
		BAH	260..>320	CDD:470629	22/66 (33%)
		JmjC	414..532	CDD:396791	57/118 (48%)