Protein Alignment KDM5A and Kdm5

DIOPT Version :10

• Sequence 1: NP_001036068.1
• Gene: KDM5A / 5927
• HGNCID: 9886
• Length: 1690
• Species: Homo sapiens
• Sequence 2: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Alignment Length: 1825
• Identity: 728/1825 - (39%)
• Similarity: 997/1825 - (54%)
• Gaps: 349/1825 - (19%)

Human    13 FVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRL 77
            |..|||||||.|:.|||.:||::|.:||.:|||.||.||.||..|.||||.:|...||.||||||
  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219

Human    78 NELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKV 142
            |||||.|||:|:||||:|||||||||:||||:||||.||||.|.:||..:||.|..||::||:||
  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284

Human   143 GSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSP-- 205
            .:|:.|...|..|:.||:||||||:|:|::.|| .::|             |...|:.:.::|
  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSG-KVLG-------------PTPTSSGSGSTPVK 335

Human   206 -EPG-----------TRMNILP---KRTRRVK----------------TQSESGDVSRNTELKK- 238
             |.|           ||..|.|   ..|||.|                |...|..|...||.|:
  Fly   336 LEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEE 400

Human   239 -----LQIF-----GAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKG----TLSVN 289
                 |..|     |..|...|....|:...                     |:||    .|.|:
  Fly   401 FKRDLLSSFNAVNSGGSPLATGTTANTRGAS---------------------QKKGGEPPALIVD 444

Human   290 FVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGF 354
            .:..|:|..|.||:.|:.:|||||||||||||||:|||..:|||:|.||:||.||.|||:|||||
  Fly   445 PLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGF 509

Human   355 EQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFG 419
            |||.||||||.||:|||.||.:||..|||:||||:||:||||:||||:|||.||||||:.:.|.|
  Fly   510 EQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHG 574

Human   420 SGFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHI 484
            ||||.|.. ..:||.::|||.|.|||||:|:||.|:|.|||.|||||..||:||||||::||||.
  Fly   575 SGFPTKSS-LYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHN 638

Human   485 EDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHG 549
            |||||||||||||||||||||||...|||.||.|::.|||||.||||||||||||||||:||.:.
  Fly   639 EDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNR 703

Human   550 VPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHE 614
            |||:||:|.|||||:|||||||:||||||||||||||..||||.:||:|||||..|||.|||||:
  Fly   704 VPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHD 768

Human   615 ELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSAC 679
            ||:.|||.:|..|..|:|.....::..|.:.|.:||:|:::.||..:|...||||.||||.|..|
  Fly   769 ELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQEC 833

Human   680 RTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVS 744
            .|||||||:.|.||.:.:|||.|.|.||.|..:|..|.|||.|:::|.:|..:||:|.|::.|:|
  Fly   834 NTTCFLSAVACECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLS 898

Human   745 RVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHR 809
            |..:.:.|:......|.||:.:.::||.:|:|.:.|..:|..|..|||.|.:|.|.|...|.:.|
  Fly   899 RCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTR 963

Human   810 QSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMM--DETPDSS 872
            ...:....:.|||:|||:.|||::.:|.|:|.:...|:.||...::|.||::..:.  .|:.:.|
  Fly   964 SDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEES 1028

Human   873 KLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLID-SGVGLAPHH 936
            :|:.||:.||||.:||.:|..|::.|:|.:|....:.......::|...:|.|:. :...|.|..
  Fly  1029 ELETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTD 1093

Human   937 A-VEKAMAELQELLTVSERWE-EKAKVCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQ 999
            . |:|.|.:||::....|.|| :.||...:...:|.:..:|..:..|.:|...:|:...||:||:
  Fly  1094 PYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALR 1158

Human  1000 KAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKK 1064
            |||||...||.:|..::..|...||::..:|..||::||.|.:::..:.:|..|::.|...||||
  Fly  1159 KAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKK 1223

Human  1065 NSSHTLLQVLSPRTD-IGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVA 1128
            .:.:|||:||.||:| |.:                     |.||:|  ..::...:.::.|.:||
  Fly  1224 GTFYTLLEVLMPRSDAINI---------------------DSDLKP--RFQDDFLKEKNPAEIVA 1265

Human  1129 VFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPK 1193
            .||..|::|:..|..||..|:.|..|.|     .||:|:......|..|:||:||||..|||.|.
  Fly  1266 SFKHAEEQELLDMRELRRQNMNKNPMRD-----MFCLCKSEFRNLMFNCQLCRDWFHEDCVPPPS 1325

Human  1194 SSSQ----KKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAM 1254
            :::|    ..||.......|:|||.|:||:||||||||.|||.||:||:||||.|||:||.||||
  Fly  1326 ATNQNGIVNGGSGPGTNRPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAM 1390

Human  1255 SWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQS 1319
            :||||||:||::.::|:|                   .|.|::.:.||              ::|
  Fly  1391 NWQDRARKALSSPDVSAA-------------------QEAIMAQQQQK--------------RRS 1422

Human  1320 AFNRVVSSVSS--SPRQTMDYDDE-----ETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDE 1377
            .....|.::||  .||:......|     |:|:|:|       |.:|...::   .:|.|...||
  Fly  1423 EGGAGVGNISSPRKPRRRGSLTKEASGSTESDADDD-------DDEDECRLR---IVEDNFSNDE 1477

Human  1378 EIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAK 1442
            :                                        :||.:| ...::...:|:|...::
  Fly  1478 D----------------------------------------EPRTAP-ATSTVNSDLLKLLSDSE 1501

Human  1443 AQ-LEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEE-------------KP 1493
            .: |.:|||.||||||||||||.:||||: |.||:      :::.::||.             .|
  Fly  1502 IENLLDLMMEGDLLEVSLDETQELWRILE-TMPPT------LLQAEAMERVVQYMQRQRQQHTNP 1559

Human  1494 LKVKGKDSSE--------------------------KKRKRKLEKVEQLFGEGKQKSKELKKMDK 1532
            |...|.:.|.                          :.:||:....      |...:...||...
  Fly  1560 LPTSGAEDSNDSLMVQNSPNSNSNSGGATGSASNSGRNKKRRSNDT------GGNSAVPRKKQST 1618

Human  1533 P-------------RKKKLKL--------GADKSKELNKLAK-------------------KLAK 1557
            |             ||...|.        |||...| ||.|.                   ....
  Fly  1619 PKQTPGKKGSAAAARKSDAKASPAASTTPGADADAE-NKQANGGNTNSSTGSGGGNSATTTPTPG 1682

Human  1558 EEERKKKKEKAAA----------------AKVELVKEST---------------EKKREKKVLDI 1591
            ...:|:|:....|                :...|...:|               :||..::
  Fly  1683 STHKKRKRTSTTATNNNNNNNNNSTNNSNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQR---- 1743

Human  1592 PSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVS-PEMAENEDYIC 1655
                ....|:|.|:|.  |.|:||.:|...:||||||||||:||||..|||:: .::..::||||
  Fly  1744 ----SQQAAQEDDEEE--CRAENCHKPTGREVDWVQCDGGCNEWFHMYCVGLNRSQIKPDDDYIC 1802

Human  1656 INCAK 1660
            |.|.|
  Fly  1803 IRCTK 1807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM5A	NP_001036068.1	JmjN	18..59	CDD:128818	24/40 (60%)
		ARID_KDM5A	84..175	CDD:350637	55/90 (61%)
		PHD1_KDM5A	295..343	CDD:277075	31/47 (66%)
		GSGFP motif. /evidence=ECO:0000250|UniProtKB:Q3UXZ9	419..423		3/3 (100%)
		JmjC	470..586	CDD:396791	93/115 (81%)
		zf-C5HC2	676..728	CDD:460750	27/51 (53%)
		PLU-1	741..1072	CDD:462475	107/335 (32%)
		PHD2_KDM5A	1163..1215	CDD:277079	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1327..1348		8/27 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1407..1433		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1509		6/57 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1516..1543		8/47 (17%)
		PHD3_KDM5A	1608..1659	CDD:277156	27/51 (53%)
		Interaction with LMO2. /evidence=ECO:0000269|PubMed:9129143	1623..1690		24/39 (62%)
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	24/40 (60%)
		ARID_JARID	226..312	CDD:350628	54/85 (64%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:396791	93/115 (81%)
		zf-C5HC2	830..882	CDD:460750	27/51 (53%)
		PLU-1	896..1231	CDD:462475	107/334 (32%)
		PHD2_KDM5A	1295..1351	CDD:277079	22/55 (40%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	27/51 (53%)