DRSC/TRiP Functional Genomics Resources

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Protein Alignment KDM5A and lid2

DIOPT Version :10

Sequence 1:NP_001036068.1 Gene:KDM5A / 5927 HGNCID:9886 Length:1690 Species:Homo sapiens
Sequence 2:NP_596174.1 Gene:lid2 / 2541299 PomBaseID:SPBP19A11.06 Length:1513 Species:Schizosaccharomyces pombe


Alignment Length:1760 Identity:376/1760 - (21%)
Similarity:624/1760 - (35%) Gaps:500/1760 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    30 TDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQL 94
            |||..|:........|.|..|:.||:.||.|...:..:|.|..:.|.||:.........|:..:|
pombe    67 TDPFKFLLDNWHTIFKNGAIKLLPPEGWQIPVVLDQGAFEFQSKRQCLNKGCLNYEKNYDYFKKL 131

Human    95 AKFWELQGSTL-KIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLG---------YL 149
            ..|.|.:|... ..|::..:.:|...|...::            |::..||.|.         ||
pombe   132 KAFHESRGLYFYHPPIIGNRPVDFLRLRNAIS------------KFTNSGSSLNNEILHKVIIYL 184

Human   150 ---PGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTRM 211
               ..|....:|...|:|.:.|:|...|         |:...|..              |..|| 
pombe   185 RLEDTKEVRQVLTRCYDRYIKPFERDSS---------PSFKSKRS--------------ESSTR- 225

Human   212 NILPKRTRRVKTQSES--GDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDA 274
               ..|..|...|.||  .:.|..:.::.:|:.|:                 .:.:|.:..|.:.
pombe   226 ---KIRNTRSSAQQESPIPETSAQSPVQTIQVNGS-----------------TSLKRPLIERGEQ 270

Human   275 FNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPK 339
                                 |.:||...|.:.:||||||:.:|||.||.|||..:||.||.|..
pombe   271 ---------------------CEYCGLDKNPETILLCDGCEAAYHTSCLDPPLTSIPKEDWYCDA 314

Human   340 C---VAEECSKPREAFGFE-QAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSS 400
            |   :::  ..||:.|.:: .:::|.:.:.|..:.:...|.                   :|.:.
pombe   315 CKFNISD--YDPRKGFKWKLSSLKERSAEIFNTLGERNSSS-------------------KLTNL 358

Human   401 IEEDVIVEYGADISSKDFG------------------SGFPVKDGRRKILPEEEEYALSGWNLNN 447
            .|:|:.:.|.:.::..:.|                  |..|.|:    :.| .|:|:...|||:|
pombe   359 TEDDIELFYWSSLAESNSGFAPLELEGLSQAYTSTIQSSLPSKE----VFP-LEKYSSEPWNLHN 418

Human   448 MPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLH---WGEPKTWYGVPSH 509
            :|.....:..:...|:|.:.:..|.:||.|.:..|   ...|.|...||   :|:..|||.:|..
pombe   419 LPFENPCLFNYSFSDLSSLTITRLSIGMVFYTHGW---TKSSLSTGLLHHHRFGDTVTWYVLPPD 480

Human   510 AAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGF 574
            .::..|..:....|:......:..:.|..|::|:.|:|:|......:....||:|..|.:||.||
pombe   481 ESDAFERYLISSYPQYTMEDLNRSNGLPVIVSPSSLIENGFHPIAIDLRPNEFLVVSPNSYHMGF 545

Human   575 NQGYNFAEAVNFCTADWLPIG--RQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVC- 636
            :||::..|:|||.|.:|:..|  ...::..:.:|.....|:|.:|..|.         |:...| 
pombe   546 HQGFSSFESVNFATVNWIKDGLLNSSISVLKSMRIPSSVSYEAVIISMV---------LSKNPCF 601

Human   637 -KELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDD-----------ERQCSACRTTCFLSALT 689
             .|..:...|:....||.       |:.|:.:|||:.           |.:||.|:..||||.:.
pombe   602 SSEWLIKCFEDMIANESA-------SKNEIMKLVPNIQALKLESSVPLEIRCSNCKQPCFLSFMQ 659

Human   690 CSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANF 754
            |. .|::.:||...............|.||:.:.:|.:|........:..:.|.:|:...||.  
pombe   660 CH-EPKKFICLGDCVKEVSLNATSWMLFYRWDVHELSNLAERFVSLIRGPEEWTNRLRSVLST-- 721

Human   755 NHKKDLIELRVMLEDAEDRKY--PENDLFRKLRDAVKEAET-------CASVAQLLLSKKQKHRQ 810
            :.|..|..|:.:|.|||....  ||.   ..|||.|:.|.:       |..||.|   |::|.::
pombe   722 SPKPQLKVLKSLLVDAEKAMLTTPET---VNLRDFVQNANSWIDSVNECLKVASL---KRKKDKK 780

Human   811 SP-----DSGRTRTKLTVEE-LKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETP 869
            .|     |.....:.|.... |...:|...|:.....:...:|....|:.||..|...:..... 
pombe   781 PPLFKAHDHWNNTSNLKDSAVLFKVLQTSRSMAFTCQEIENMKQKAFDLLEFRNRLINSFSGPL- 844

Human   870 DSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLD------EVRLTLSDPQQVTLDVMKKLIDS 928
            |.:..|.|:.....|...:|||..:::.|.|..|||      ..|.|.||        :::||..
pombe   845 DKNTCQRLLTEAELLGFTIPELGIIQKYLIQFEWLDMFYSFETTRTTDSD--------LERLITY 901

Human   929 GVGLA-----PHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNEAKNI---P 985
            ||...     .:....|||....|:      ||.:....| ::...|...|..:.:||.|:   .
pombe   902 GVSAGIPEDNDYMIFAKAMKGRAEI------WENQVYDTL-SKSNISYDKLSLLRDEAMNLCVNK 959

Human   986 AFLPNVLSLKEALQKAREWTAKVEAIQSGS---NYAY---LEQLESLSAKGRPIPVRLEALPQVE 1044
            .....|:.:   |..|.|...|:..:...|   ::|.   :::::...|....:|:..|:...::
pombe   960 ELFSKVVGI---LNNAEEIKNKIATLCERSQEKDFALRPSIDEVKEALASAEKLPILSESTVTLQ 1021

Human  1045 SQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDL-- 1107
            ........|..|..|.|.|.|:.   |::|....|                .:||.....|.|  
pombe  1022 KMYDVVLEWIRRGKRLFGKANAP---LEILGQHLD----------------YVEKRNSASLSLND 1067

Human  1108 EPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASG 1172
            .|...:|....||              ..:.|...::|           :.:...||.||...||
pombe  1068 RPGPPMEPASRET--------------SPDSEGRLTIR-----------KKKGCIFCFCRLPESG 1107

Human  1173 FMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLC-------MRSRRPRLETILSLL 1230
            .|::||:|.:|:|..|:.:.|...:        ::.||.||:|       ..|.||:||.:.||.
pombe  1108 VMIECEICHEWYHAKCLKMSKKKLR--------QDEKFTCPICDYRVEIPRLSNRPKLEDLQSLY 1164

Human  1231 VSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKI 1295
            ..::.||.:..|.|.|:.:.:.|..:: :..||||.:.....:|::.:         ||....|:
pombe  1165 KDVKLLPFQPKETETLRKVVDLASKFR-QEMQALAHNPFGLTMAEVPL---------ARFYLRKM 1219

Human  1296 ISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDT 1360
            ..||:.                                                       :.| 
pombe  1220 EGAEIL-------------------------------------------------------LVD- 1228

Human  1361 ASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPL 1425
                     |.|||..     |..|.|......|....|          |:.:..||...|:..:
pombe  1229 ---------ETNLFRQ-----KLHECVPIAPNPPPIIGE----------SKSTRKPRPTKRQRQI 1269

Human  1426 VPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSME 1490
            :.:..|                     .||..|            |..||               
pombe  1270 MKQVAE---------------------GLLPAS------------AIAPP--------------- 1286

Human  1491 EKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKL 1555
                    |.|:|||....::.||   .|.|.||::     .|:|.    |.:.|...||....:
pombe  1287 --------KSSNEKKSSNNVKAVE---AETKSKSEK-----SPKKN----GTNISDANNKNESHV 1331

Human  1556 AKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCK 1620
            :    ..|..:..:.|.|.||||                           :|:.|.   |.....
pombe  1332 S----LMKNWKLGSPAFVTLVKE---------------------------KNSSCL---CGEEFS 1362

Human  1621 DKVDWVQCDGGCDEWFHQVCVGVSPEMAEN-EDYICINCAKKQGPVSPGPAPP-----PSFIMSY 1679
            .:..::.|. .|:..||..|||::.|:|:: ..:.|..|.::.|.:.|....|     |..|..:
pombe  1363 PRDSFIDCT-ICERRFHYDCVGLNNEIADSVSKFTCPICMEQSGGIYPWQLRPRNGMHPDHISGF 1426

Human  1680 KLPME 1684
            ...:|
pombe  1427 SKEVE 1431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDM5ANP_001036068.1 JmjN 18..59 CDD:128818 10/28 (36%)
ARID_KDM5A 84..175 CDD:350637 20/103 (19%)
PHD1_KDM5A 295..343 CDD:277075 24/50 (48%)
GSGFP motif. /evidence=ECO:0000250|UniProtKB:Q3UXZ9 419..423 2/21 (10%)
JmjC 470..586 CDD:396791 34/118 (29%)
zf-C5HC2 676..728 CDD:460750 15/51 (29%)
PLU-1 741..1072 CDD:462475 83/365 (23%)
PHD2_KDM5A 1163..1215 CDD:277079 18/51 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1348 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1407..1433 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1490..1509 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1516..1543 7/26 (27%)
PHD3_KDM5A 1608..1659 CDD:277156 12/51 (24%)
Interaction with LMO2. /evidence=ECO:0000269|PubMed:9129143 1623..1690 17/68 (25%)
lid2NP_596174.1 ARID 122..208 CDD:198082 19/97 (20%)
PHD1_Lid2p_like 270..315 CDD:276994 23/65 (35%)
cupin_RmlC-like 441..557 CDD:477354 34/118 (29%)
zf-C5HC2 646..697 CDD:460750 15/51 (29%)
PLU-1 710..1049 CDD:462475 84/368 (23%)
PHD_Ecm5p_Lid2p_like 1098..1142 CDD:276993 18/51 (35%)
PHD3_Lid2p_like 1354..1400 CDD:276995 12/49 (24%)

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