Protein Alignment KDM5A and rbr-2

DIOPT Version :10

• Sequence 1: NP_001036068.1
• Gene: KDM5A / 5927
• HGNCID: 9886
• Length: 1690
• Species: Homo sapiens
• Sequence 2: NP_502032.2
• Gene: rbr-2 / 177985
• WormBaseID: WBGene00004319
• Length: 1477
• Species: Caenorhabditis elegans
• Alignment Length: 1748
• Identity: 478/1748 - (27%)
• Similarity: 753/1748 - (43%)
• Gaps: 434/1748 - (24%)

Human    12 EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQR 76
            :||.||..|::.|:.|||:||:.::.:||..|||.|:.||.||.:::||||.:.::|.|.||.|:
 Worm    49 KFVRPPMAPIYYPTEEEFSDPIEYVAKIRHEAEKFGVVKIVPPANFKPPFAIDKEAFTFRPRTQK 113

Human    77 LNELEAMTRVRLDFLDQLAKFWELQGSTLKIPV-VERKILDLYALSKIVASKGGFEMVTKEKKWS 140
            |||:||:.:.:..|:|:|..|....|.|.:.|| .:..|:|||.|.:||.:.||.|.|.:::||.
 Worm   114 LNEVEAIVKEKHTFIDRLINFNRYSGLTFEFPVDRDGNIVDLYRLHRIVQNFGGCEEVNEDEKWR 178

Human   141 KVGSRLGYLP----GKGTGS----LLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVL 197
            .|...  |||    .:|..|    |::|||...:.|:               |.:||||    .:
 Worm   179 DVARE--YLPKEQMARGVPSAFINLIRSHYNLHIEPF---------------NRNLKEK----AM 222

Human   198 STDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGT---KDKE 259
            ..|.::..|    |..|     :.|.|...|.:....|:...:....|.....::|.:   :.|.
 Worm   223 KNDDESDDE----MEEL-----KHKYQHHHGTMRTEIEVPNDKTTEGGEDECPVSMQSGRRRSKN 278

Human   260 DEVTRRRKVTNRSDAFNMQMRQRKGTLSV--------NFVDLYVCMFCGRGNNEDKLLLC--DGC 314
            .:.:..||....|...| ..|.||.....        :.:|...|:.|..|.:||.||||  |||
 Worm   279 KKASSSRKTLGTSSKKN-STRGRKNKKKAEGDDDDDEDPMDQVFCVACNEGKDEDLLLLCDIDGC 342

Human   315 DDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVREYTLQSFGEMADNFKSDYFN 379
            ::..||:|..|.|.:||:|:||||||:..|.:|....:||..|..||.|.||.|.|:.:|.|||.
 Worm   343 NNGRHTYCCDPVLDEVPEGEWRCPKCIESEDAKIGLDWGFYDADTEYNLNSFTEFANKWKCDYFG 407

Human   380 M-PVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRR--KILPEEEEYALS 441
            : .|..|..:.||:.||:.|.|.|..|.|:||||:.:...|||||.|:.:.  ..|..:::||..
 Worm   408 VKDVSQVSCDAVERSFWKNVISHENPVSVKYGADLITSRVGSGFPRKEDKHTGPDLKLKQQYASH 472

Human   442 GWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGV 506
            .|||||||||.:|||:|.|..||||.|||:|||||||:||||.||||:||:||.|:||.|.||||
 Worm   473 AWNLNNMPVLRESVLSHFNTGISGMMVPWVYVGMCFSTFCWHTEDHWTYSVNYNHFGERKIWYGV 537

Human   507 PSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYH 571
            ....||:.|:.::::||.|...|.||.|.:.|..||::|...|||::..:|.|||||:|||||||
 Worm   538 GGEDAEKFEDALKKIAPGLTGRQRDLFHHMTTAANPHLLRSLGVPIHSVHQNAGEFVITFPRAYH 602

Human   572 SGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVC 636
            :|||:|.||||||||...|||..||:||..|..:||:.||||:||:|||....:.|.:.::....
 Worm   603 AGFNEGLNFAEAVNFAPIDWLSKGRECVESYSNVRRYLVFSHDELLFKMVEAMDKLGISMSLATH 667

Human   637 KELTLMTEEETRLRESVVQMGV--LMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVC 699
            :||..:.|::..|||.:.::||  ...::.:||.:||::|.|..|:||.|:.||.|: ..:::.|
 Worm   668 EELIRIYEKQKMLRELLARLGVSNRQMQQVMFEKIPDEQRSCRFCKTTLFMCALVCN-KHKKMTC 731

Human   700 LYHPTDLC-PCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIEL 763
            :.|...|| .|..:....:||:.|:.|.::...:..|..:|:.|.....|.|......|.:.||
 Worm   732 VEHHDHLCNSCTTKDYRYQYRFELDQLNNMCDELGKRTVNYNGWKEESDEMLEEEGKPKLERIE- 795

Human   764 RVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKA 828
             ..::.|:..|||:.|...||......|::....|..||.||.:.|......|..|:...|.:::
 Worm   796 -EFIDSAKQNKYPQTDQVHKLITIRHTAKSAIEKANQLLFKKVRTRTKTRCQRADTRTDTEGVRS 859

Human   829 FVQQLFSLPCVISQ-ARQVKNLLDDVEEFHERAQEAMMDETPDS-SKLQMLIDMGSSLYVELPEL 891
            .::|:.::.|.::. ..:::..::.||.:..||::|:..|...| .:::.:|:.|....::|.|:
 Worm   860 LIEQMQAMDCNLTVIIDKLEKWMEQVEMWRNRAKDAIYREQEYSKEEIEKIIEEGDEYDIKLEEI 924

Human   892 PRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLA----------------PHHAVEK 940
            ..|::.:|...|.|..|...:  .:.|.| |:|.||....|.                |.....|
 Worm   925 DELRKVIQMKDWSDRARKVTT--WKATPD-MEKDIDFEYKLRYASSDILSLIRDSPRNPTDGTSK 986

Human   941 AMAELQELL--------------------TVSERWE---------EKAKVCLQARPRHSVASLES 976
            .:.|||::|                    .:...|:         ||....::....| ||.::|
 Worm   987 LVFELQQMLRDANTLEVIANNFCENPALDQLQSIWQSLRETDWFYEKYINMVRYEIIH-VAKIKS 1050

Human   977 IVNEAKNIPAF--------LPNVLSLKEALQKAREWTAKVEAIQ--SGSNYAYLEQLESLSAKGR 1031
            :::.|  ||..        |..:::::..|.||.|.:...|..:  :||.    |.|..|
 Worm  1051 MIDAA--IPVLSEFDLKTQLQKIVNVEITLSKAAEISKAFETSKCLNGSE----EHLGIL----- 1104

Human  1032 PIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKN-----RRK 1091
                         ..::...|:.:|....|...|:.|.|.::||.|.|:.....|:.     :..
 Worm  1105 -------------DMISTMNAFTQRIAILFKPNNAYHNLFEILSERDDLTPLAEGQTIPLYFQGG 1156

Human  1092 KVKELIEKEKEKDLD-LEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMV 1155
            .|....|..:.|:.: |:.:...:..|.|     |.:.:|::.:|           ||.|:
 Worm  1157 AVHPSDEWHQMKEFESLDQIVHHQSSLRE-----MQMRIFEKVKQ-----------ANSAR---- 1201

Human  1156 DRIEEVKFCIC----RKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSW-----QAKEVKFL 1211
                .::.|.|    :...|...|.|.:|...||..|            ..|     :..|..||
 Worm  1202 ----GLEACSCLGFNKSDDSESTLTCIMCDSEFHVRC------------CEWSPFLEKLPEGCFL 1250

Human  1212 CPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKL 1276
            |..|:|.:||.::.:.:.|..       .|.|                   .|.|..:.:.:.|.
 Worm  1251 CVRCLRGQRPVIDDVTTALNG-------TPSG-------------------CLETHLVRNLIQKT 1289

Human  1277 SVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDDE 1341
            ..::|.::|.|.:.|:
 Worm  1290 RGITQNLMEAANKRKS------------------------------------------------- 1305

Human  1342 ETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSAS 1406
             .:|.:||.:...:|.      .|...|.||     .:| |:.|:::      .|..|:....:|
 Worm  1306 -GESSDDICKIALFDW------LSCEILNPN-----GLP-KARELIS------EFYMEYLQKQSS 1351

Human  1407 KSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQA 1471
            .:....:...|.:|..|...|:.
 Worm  1352 AALELKNRPVRSKPSVSLFDPKI------------------------------------------ 1374

Human  1472 THPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKK 1536
                            :.:.|...|..|::|:|.|||:           .|.|
 Worm  1375 ----------------TAKRKRPSVSHKETSKKSRKRQ-----------SQAS------------ 1400

Human  1537 KLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAE 1601
                                                                   ||:|     .
 Worm  1401 -------------------------------------------------------PSEY-----Y 1405

Human  1602 ESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVS-PEMAENEDYICINC 1658
            |.:.|...|.|:.|.:|..|.|:||.|:.||..|||.:|:|.: .|:.:..:|.|.:|
 Worm  1406 EDESEFKSCQARACLKPYGDSVNWVMCEAGCKNWFHVICLGFTLREINDMHEYRCSSC 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM5A	NP_001036068.1	JmjN	18..59	CDD:128818	17/40 (43%)
		ARID_KDM5A	84..175	CDD:350637	32/99 (32%)
		PHD1_KDM5A	295..343	CDD:277075	26/49 (53%)
		GSGFP motif. /evidence=ECO:0000250|UniProtKB:Q3UXZ9	419..423		3/3 (100%)
		JmjC	470..586	CDD:396791	68/115 (59%)
		zf-C5HC2	676..728	CDD:460750	17/52 (33%)
		PLU-1	741..1072	CDD:462475	81/387 (21%)
		PHD2_KDM5A	1163..1215	CDD:277079	14/60 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1327..1348		1/20 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1407..1433		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1509		7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1516..1543		2/26 (8%)
		PHD3_KDM5A	1608..1659	CDD:277156	20/52 (38%)
		Interaction with LMO2. /evidence=ECO:0000269|PubMed:9129143	1623..1690		15/37 (41%)
rbr-2	NP_502032.2	JmjN	55..96	CDD:128818	17/40 (43%)
		BRIGHT	122..214	CDD:128777	32/108 (30%)
		PHD_SF	321..368	CDD:473978	24/46 (52%)
		JmjC	501..617	CDD:396791	68/115 (59%)
		zf-C5HC2	709..761	CDD:460750	17/52 (33%)
		PLU-1	787..1132	CDD:462475	78/374 (21%)
		PHD	1208..1254	CDD:214584	13/57 (23%)
		PHD3_KDM5A_like	1413..1463	CDD:277083	19/49 (39%)