DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc2 and Mccc2

DIOPT Version :9

Sequence 1:	NP_652724.1	Gene:	Mccc2 / 59261	FlyBaseID:	FBgn0042083	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_084302.1	Gene:	Mccc2 / 78038	MGIID:	1925288	Length:	563	Species:	Mus musculus

Alignment Length:	559	Identity:	390/559 - (69%)
Similarity:	446/559 - (79%)	Gaps:	16/559 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RLLHVGDANVLHSEVDKQSAEYKENAREMASLVGDLRNFTSQVLKGGGQKAIERHTSRGKLLARE 84
            |..|......|.::.|..|:.|:||..:|.:||..|......|..||.:||..|||||||||.|:
Mouse    21 RAYHGDSVARLGTQPDSASSTYQENYEQMKALVSQLHERAQYVRLGGSEKARARHTSRGKLLPRD 85

  Fly    85 RINLLLDKGSPFLELSALAGHELYGEEVVNSGGIVTGVGRVCGTECLVVANDATVKGGSYYPITV 149
            ||:.|:|.||||||.|..||::|||:|.|.:|||:||:|||.|.||::||||||||||:|||:||
Mouse    86 RIDNLIDPGSPFLEFSQFAGYQLYGDEEVPAGGIITGIGRVSGVECMIVANDATVKGGTYYPVTV 150

  Fly   150 KKHLRAQEIAQENRLPCIYLVDSGGANLPRQADVFPDKLHFGRIFYNQANMSAQGIPQIAVVMGS 214
            |||:||||||.:|||||||||||||||||||||.|||:.||||||||||.||::.|.||||||||
Mouse   151 KKHVRAQEIALQNRLPCIYLVDSGGANLPRQADTFPDRDHFGRIFYNQAIMSSKNITQIAVVMGS 215

  Fly   215 CTAGGAYVPAMADESIIVKKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCKTSGVTDHYALDD 279
            ||||||||||||||:|||:|||||||||||||||||||||||||||||||||:.|||||||||||
Mouse   216 CTAGGAYVPAMADENIIVQKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVTDHYALDD 280

  Fly   280 EHALYLARQIVSNLNLSATNSYNDQLMHSSQVNFQTATPPSAVEEPRYDAEELYGIVGPNLTKSF 344
            .|||:|.|::|.:||.              |........||  |||.:.|:|||||||.||.:||
Mouse   281 HHALHLTRKVVRSLNY--------------QKKMDVTIEPS--EEPLFPADELYGIVGANLKRSF 329

  Fly   345 DVREVIARIVDGSRFTEFKKLYGETLVCGFAKLYGHTVGIVGNNGVLFSESALKGAHFIQLCAQR 409
            |||||||||||||||.|||.|||:|||.|||:::|:.|||:|||||||||||.|||||:|||.||
Mouse   330 DVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPVGIIGNNGVLFSESAKKGAHFVQLCCQR 394

  Fly   410 KIPLVFLQNITGFMVGRDAEANGIAKNGAKMVTAVACANVPKFTVIIGGSYGAGNYGMCGRAYSP 474
            .|||:|||||||||||||.||.||||:|||||.|||||.|||.||||||||||||||||||||||
Mouse   395 NIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVAAVACAKVPKITVIIGGSYGAGNYGMCGRAYSP 459

  Fly   475 RFLYMWPNSRISVMGGTQAANVMAQITEDQRKRAGKEFSEEEAQKLKAPIVEMFEAEGSPYYSTA 539
            ||||||||:|||||||.|||.|:|.:..||:.|.||:||..|...||.||::.||.||:||||:|
Mouse   460 RFLYMWPNARISVMGGEQAATVLATVARDQKAREGKQFSSAEEAALKEPIIKRFEEEGNPYYSSA 524

  Fly   540 RLWDDGIIDPANTRQILGLSLKAALNNAGQETKFGVFRM 578
            ||||||||||.:||.:|||||.||||...|.|.||:|||
Mouse   525 RLWDDGIIDPVDTRLVLGLSLSAALNAPIQRTDFGIFRM 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc2	NP_652724.1	PLN02820	27..578	CDD:178415	386/550 (70%)
		crotonase-like	<82..254	CDD:304874	135/171 (79%)
		crotonase-like	<359..>487	CDD:304874	105/127 (83%)
Mccc2	NP_084302.1	PLN02820	8..563	CDD:178415	379/541 (70%)
		Carboxyltransferase. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01138	49..555		365/505 (72%)
		crotonase-like	<84..255	CDD:304874	135/170 (79%)
		Acyl-CoA binding. /evidence=ECO:0000255	343..372		24/28 (86%)
		crotonase-like	<344..535	CDD:304874	147/190 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837252
Domainoid	1	1.000	737	1.000	Domainoid score	I101
eggNOG	1	0.900	-	-		E1_COG4799
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11145
Inparanoid	1	1.050	777	1.000	Inparanoid score	I528
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62385
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004920
OrthoInspector	1	1.000	-	-		oto92751
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2629
SonicParanoid	1	1.000	-	-		X4587
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.890