DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc2 and Pccb

DIOPT Version :9

Sequence 1:	NP_652724.1	Gene:	Mccc2 / 59261	FlyBaseID:	FBgn0042083	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_080111.1	Gene:	Pccb / 66904	MGIID:	1914154	Length:	541	Species:	Mus musculus

Alignment Length:	519	Identity:	174/519 - (33%)
Similarity:	254/519 - (48%)	Gaps:	81/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LKGGGQKAIERHTSRGKLLARERINLLLDKGSPFLELSALAGHEL--YG----EEVVNSGGIVTG 121
            |.||||:.|:....||||.|||||:||||.|| |:|......|..  :|    :.......:|||
Mouse    49 LLGGGQRRIDAQHKRGKLTARERISLLLDPGS-FMESDMFVEHRCADFGMAADKNKFPGDSVVTG 112

  Fly   122 VGRVCGTECLVVANDATVKGGSYYPITVKKHLRAQEIAQENRLPCIYLVDSGGA-------NLPR 179
            .||:.|....|.:.|.||.|||......:|..:..:.|.....|.|.|.|||||       :|..
Mouse   113 RGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAG 177

  Fly   180 QADVFPDKLHFGRIFYNQANMSAQG-IPQIAVVMGSCTAGGAYVPAMADESIIVKKQGTIFLAGP 243
            .||:|            ..|::|.| ||||:::||.|..|..|.||:.|.:.:||....:|:.||
Mouse   178 YADIF------------LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGP 230

  Fly   244 PLVKAATGEEVSAEDLGGADLHCKTSGVTDHYALD-DEHALYLARQIVSNLNLSATNSYNDQLMH 307
            .:||:.|.|:|:.|.||||..|...|||. |.|.| |..||...|:..:.|.||:.:
Mouse   231 EVVKSVTNEDVTQEQLGGAKTHTTVSGVA-HRAFDNDVDALCNLREFFNFLPLSSQD-------- 286

  Fly   308 SSQVNFQTATPPSAVEEPRYDAE----ELYGIVGPNLTKSFDVREVIARIVDGSRFTEFKKLYGE 368
                       |:.:.|....::    ||..:|....:|::::.::|..::|...|.|....|.:
Mouse   287 -----------PAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPSYAK 340

  Fly   369 TLVCGFAKLYGHTVGIVGN-----NGVLFSESALKGAHFIQLCAQRKIPLVFLQNITGFMVGRDA 428
            .:|.|||::.|.|||||||     :|.|...|::|||.|::.|....|||:...::.||:.|...
Mouse   341 NIVVGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQ 405

  Fly   429 EANGIAKNGAKMVTAVACANVPKFTVIIGGSYGAGNYGMCGRAYSPRFL----YMWPNSRISVMG 489
            |..||.::|||::.|.|.|.|||.|||...:|| |.|.:..   |...|    |.||.:.|:|||
Mouse   406 EYGGIIRHGAKLLYAFAEATVPKITVITRKAYG-GAYDVMS---SKHLLGDTNYAWPTAEIAVMG 466

  Fly   490 GTQAANVMAQITEDQRKRAGKEFSEEEAQKLKAPIVEMFEAEGSPYYSTARLWDDGIIDPANTR 553
            ...|..::.:             ..::.:..:|..||.|   .:|:.:..|.:.|.||.|::||
Mouse   467 AKGAVEIIFK-------------GHQDVEAAQAEYVEKF---ANPFPAAVRGFVDDIIQPSSTR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc2	NP_652724.1	PLN02820	27..578	CDD:178415	174/519 (34%)
		crotonase-like	<82..254	CDD:304874	66/185 (36%)
		crotonase-like	<359..>487	CDD:304874	54/136 (40%)
Pccb	NP_080111.1	Carboxyltransferase. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01138	34..535		174/519 (34%)
		MmdA	39..541	CDD:227136	174/519 (34%)
		crotonase-like	65..>212	CDD:304874	57/159 (36%)
		crotonase-like	<319..509	CDD:304874	68/209 (33%)
		Acyl-CoA binding. /evidence=ECO:0000255	327..360		15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4799
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2393
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760