Protein Alignment Mccc2 and PCCB

DIOPT Version :10

• Sequence 1: NP_652724.1
• Gene: Mccc2 / 59261
• FlyBaseID: FBgn0042083
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_001171485.1
• Gene: PCCB / 5096
• HGNCID: 8654
• Length: 559
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 188/594 - (31%)
• Similarity: 268/594 - (45%)
• Gaps: 128/594 - (21%)

  Fly    12 SVL---LRSQVRLLHVGDANVLHSEVDKQSAEYKENAREMASLVGDLRNFTSQVLKGGGQKAIER 73
            |||   ||:.||.| ...|..::..:        ||.|..|             |.||||:.|:.
Human    15 SVLASGLRAAVRSL-CSQATSVNERI--------ENKRRTA-------------LLGGGQRRIDA 57

  Fly    74 HTSRGKLLARERINLLLDKGSPFLELSALAGHEL--YG----EEVVNSGGIVTGVGRVCG----- 127
            ...||||.|||||:||||.|| |:|......|..  :|    :.......:|||.||:.|
Human    58 QHKRGKLTARERISLLLDPGS-FVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVYV 121

  Fly   128 ---------------TECLVVANDATVKGGSYYPITVKKHLRAQEIAQENRLPCIYLVDSGGA-- 175
                           ...|..|.|.||.|||......:|..:..:.|.....|.|.|.|||||
Human   122 FSQQIIGWAQWLPLVISALWEAEDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARI 186

  Fly   176 -----NLPRQADVFPDKLHFGRIFYNQANMSAQG-IPQIAVVMGSCTAGGAYVPAMADESIIVKK 234
                 :|...||:|            ..|::|.| ||||:::||.|..|..|.||:.|.:.:||.
Human   187 QEGVESLAGYADIF------------LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKD 239

  Fly   235 QGTIFLAGPPLVKAATGEEVSAEDLGGADLHCKTSGVTDHYALDDEHALYLARQIVSNLNLSATN 299
            ...:|:.||.:||:.|.|:|:.|:||||..|...|||......:|..||...|...:.|.||:.:
Human   240 TSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPLSSQD 304

  Fly   300 SYNDQLMHSSQVNFQTATPPSAVEEPRYDAE----ELYGIVGPNLTKSFDVREVIARIVDGSRFT 360
                               |:.|.|....::    ||..||....||::::.::|..:||...|.
Human   305 -------------------PAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFF 350

  Fly   361 EFKKLYGETLVCGFAKLYGHTVGIVGN-----NGVLFSESALKGAHFIQLCAQRKIPLVFLQNIT 420
            |....|.:.::.|||::.|.|||||||     :|.|...|::|||.|::.|....|||:...::.
Human   351 EIMPNYAKNIIVGFARMNGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVP 415

  Fly   421 GFMVGRDAEANGIAKNGAKMVTAVACANVPKFTVIIGGSYGAGNYG------MCGRAYSPRFLYM 479
            ||:.|...|..||.::|||::.|.|.|.|||.|||...:|| |.|.      :||...     |.
Human   416 GFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYG-GAYDVMSSKHLCGDTN-----YA 474

  Fly   480 WPNSRISVMGGTQAANVMAQITEDQRKRAGKEFSEEEAQKLKAPIVEMFEAEGSPYYSTARLWDD 544
            ||.:.|:|||...|..::.:             ..|..:..:|..:|.|   .:|:.:..|.:.|
Human   475 WPTAEIAVMGAKGAVEIIFK-------------GHENVEAAQAEYIEKF---ANPFPAAVRGFVD 523

  Fly   545 GIIDPANTR 553
            .||.|::||
Human   524 DIIQPSSTR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mccc2	NP_652724.1	Carboxyl_trans	27..578	CDD:481543	180/576 (31%)
PCCB	NP_001171485.1	MmdA	37..557	CDD:443827	179/571 (31%)