DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc2 and mccc2

DIOPT Version :9

Sequence 1:	NP_652724.1	Gene:	Mccc2 / 59261	FlyBaseID:	FBgn0042083	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_998092.1	Gene:	mccc2 / 405863	ZFINID:	ZDB-GENE-040426-2493	Length:	566	Species:	Danio rerio

Alignment Length:	574	Identity:	398/574 - (69%)
Similarity:	463/574 - (80%)	Gaps:	19/574 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WLFRSSSVLLRSQV-RLLHVGDANVLHSEVDKQSAEYKENAREMASLVGDLRNFTSQVLKGGGQK 69
            :|.||.||  .:.| ||.|......:.|:.|.||..::||...|.:||.:|::...::..|||:|
Zfish    11 FLIRSRSV--NAAVSRLYHADKVATVGSQPDTQSPVFQENYERMQALVKELKDRAEKIKLGGGEK 73

  Fly    70 AIERHTSRGKLLARERINLLLDKGSPFLELSALAGHELYGEEVVNSGGIVTGVGRVCGTECLVVA 134
            |...||||||||.||||:.|||.||||||.|..|.::|||:|.|.:|||:||:|||.|.|||:||
Zfish    74 ARNLHTSRGKLLPRERIDRLLDPGSPFLEFSQFAAYQLYGKEEVPAGGIITGIGRVSGVECLIVA 138

  Fly   135 NDATVKGGSYYPITVKKHLRAQEIAQENRLPCIYLVDSGGANLPRQADVFPDKLHFGRIFYNQAN 199
            ||||||||:|||:|||||||||||||:|.||||||||||||||.||||||||:.||||||:|||.
Zfish   139 NDATVKGGTYYPVTVKKHLRAQEIAQQNHLPCIYLVDSGGANLSRQADVFPDRDHFGRIFFNQAR 203

  Fly   200 MSAQGIPQIAVVMGSCTAGGAYVPAMADESIIVKKQGTIFLAGPPLVKAATGEEVSAEDLGGADL 264
            :|::||.||||||||||||||||||||||||||:|||||||.|||||||||||||||||||||||
Zfish   204 LSSEGISQIAVVMGSCTAGGAYVPAMADESIIVRKQGTIFLGGPPLVKAATGEEVSAEDLGGADL 268

  Fly   265 HCKTSGVTDHYALDDEHALYLARQIVSNLNLSATNSYNDQLMHSSQVNFQTATPPSAVEEPRYDA 329
            ||:.|||||||||||.|||:|||:.|.:||      |...|       ..|..||   |.|.:.|
Zfish   269 HCRKSGVTDHYALDDNHALHLARKAVRSLN------YKKNL-------DVTVEPP---EAPLFPA 317

  Fly   330 EELYGIVGPNLTKSFDVREVIARIVDGSRFTEFKKLYGETLVCGFAKLYGHTVGIVGNNGVLFSE 394
            :|||||||.||.::||:|||||||||||:|.|||..||:||:.|||:::|:.|||:|||||||||
Zfish   318 DELYGIVGDNLKRNFDIREVIARIVDGSKFDEFKAFYGDTLITGFARIFGYPVGIIGNNGVLFSE 382

  Fly   395 SALKGAHFIQLCAQRKIPLVFLQNITGFMVGRDAEANGIAKNGAKMVTAVACANVPKFTVIIGGS 459
            ||.||.|||:||.||.|||:||||||||||||:.||.||||:|||||||||||||||.|||||||
Zfish   383 SAKKGTHFIELCCQRNIPLLFLQNITGFMVGREYEAGGIAKDGAKMVTAVACANVPKITVIIGGS 447

  Fly   460 YGAGNYGMCGRAYSPRFLYMWPNSRISVMGGTQAANVMAQITEDQRKRAGKEFSEEEAQKLKAPI 524
            |||||||||||||.|||||||||||||||||.|||.|:|.||:||:.|.||||:.|:...:|.||
Zfish   448 YGAGNYGMCGRAYGPRFLYMWPNSRISVMGGEQAATVLATITKDQKAREGKEFTAEQEAAMKEPI 512

  Fly   525 VEMFEAEGSPYYSTARLWDDGIIDPANTRQILGLSLKAALNNAGQETKFGVFRM 578
            ::.||.||:||||:||||||||||||:||.:|||||.||||...|:|:||||||
Zfish   513 IKRFEEEGNPYYSSARLWDDGIIDPADTRLVLGLSLSAALNAPTQKTRFGVFRM 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc2	NP_652724.1	PLN02820	27..578	CDD:178415	387/550 (70%)
		crotonase-like	<82..254	CDD:304874	137/171 (80%)
		crotonase-like	<359..>487	CDD:304874	103/127 (81%)
mccc2	NP_998092.1	PLN02820	39..566	CDD:178415	386/542 (71%)
		crotonase-like	<87..258	CDD:304874	137/170 (81%)
		crotonase-like	<347..>485	CDD:304874	111/137 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580854
Domainoid	1	1.000	737	1.000	Domainoid score	I103
eggNOG	1	0.900	-	-		E1_COG4799
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11145
Inparanoid	1	1.050	785	1.000	Inparanoid score	I499
OMA	1	1.010	-	-		QHG62385
OrthoDB	1	1.010	-	-		D194285at33208
OrthoFinder	1	1.000	-	-		FOG0004920
OrthoInspector	1	1.000	-	-		oto39579
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2629
SonicParanoid	1	1.000	-	-		X4587
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900