DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc2 and Mccc2

DIOPT Version :9

Sequence 1:	NP_652724.1	Gene:	Mccc2 / 59261	FlyBaseID:	FBgn0042083	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001012177.1	Gene:	Mccc2 / 361884	RGDID:	1310279	Length:	563	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	391/560 - (69%)
Similarity:	449/560 - (80%)	Gaps:	18/560 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RLLHVGDANV-LHSEVDKQSAEYKENAREMASLVGDLRNFTSQVLKGGGQKAIERHTSRGKLLAR 83
            |..| |||.. |.::.|..|:.|:||..:|.:||..|......|..||.:||..|||||||||.|
  Rat    21 RAYH-GDAVARLGTQPDSGSSTYQENYEQMKALVNQLHERAQYVRLGGSEKARARHTSRGKLLPR 84

  Fly    84 ERINLLLDKGSPFLELSALAGHELYGEEVVNSGGIVTGVGRVCGTECLVVANDATVKGGSYYPIT 148
            :||:.|:|.||||||.|..||::|||||.|.:|||:||:|||.|.||::||||||||||:|||:|
  Rat    85 DRIDNLIDPGSPFLEFSQFAGYKLYGEEEVPAGGIITGIGRVSGVECMIVANDATVKGGTYYPVT 149

  Fly   149 VKKHLRAQEIAQENRLPCIYLVDSGGANLPRQADVFPDKLHFGRIFYNQANMSAQGIPQIAVVMG 213
            ||||:||||||.:|||||||||||||||||||||.|||:.||||||||||.||::.|.|||||||
  Rat   150 VKKHVRAQEIALQNRLPCIYLVDSGGANLPRQADTFPDRDHFGRIFYNQAIMSSKNITQIAVVMG 214

  Fly   214 SCTAGGAYVPAMADESIIVKKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCKTSGVTDHYALD 278
            |||||||||||||||:|||::||||||||||||||||||||||||||||||||:.||||||||||
  Rat   215 SCTAGGAYVPAMADENIIVQRQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRRSGVTDHYALD 279

  Fly   279 DEHALYLARQIVSNLNLSATNSYNDQLMHSSQVNFQTATPPSAVEEPRYDAEELYGIVGPNLTKS 343
            |.|||:|.|::|.:||.              |........||  |||.:.|:|||||||.||.:|
  Rat   280 DHHALHLTRKVVRSLNY--------------QKKLDVTVEPS--EEPLFPADELYGIVGANLKRS 328

  Fly   344 FDVREVIARIVDGSRFTEFKKLYGETLVCGFAKLYGHTVGIVGNNGVLFSESALKGAHFIQLCAQ 408
            ||||||||||||||||.|||.|||:|||.|||:::|:.|||:|||||||||||.|||||:|||.|
  Rat   329 FDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPVGIIGNNGVLFSESAKKGAHFVQLCCQ 393

  Fly   409 RKIPLVFLQNITGFMVGRDAEANGIAKNGAKMVTAVACANVPKFTVIIGGSYGAGNYGMCGRAYS 473
            |.|||:|||||||||||:|.||.||||:|||||.||:||.|||.|||||||||||||||||||||
  Rat   394 RNIPLLFLQNITGFMVGKDYEAEGIAKDGAKMVAAVSCAKVPKITVIIGGSYGAGNYGMCGRAYS 458

  Fly   474 PRFLYMWPNSRISVMGGTQAANVMAQITEDQRKRAGKEFSEEEAQKLKAPIVEMFEAEGSPYYST 538
            |||||||||:|||||||.|||.|:|.:..|||.|.||:||..|...||.||::.||.||:||||:
  Rat   459 PRFLYMWPNARISVMGGEQAATVLATVARDQRAREGKQFSSAEEAALKEPIIKRFEEEGNPYYSS 523

  Fly   539 ARLWDDGIIDPANTRQILGLSLKAALNNAGQETKFGVFRM 578
            |||||||||||.:||.:||||:.||||...|.|.||:|||
  Rat   524 ARLWDDGIIDPVDTRLVLGLSISAALNAPIQRTDFGIFRM 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc2	NP_652724.1	PLN02820	27..578	CDD:178415	385/551 (70%)
		crotonase-like	<82..254	CDD:304874	135/171 (79%)
		crotonase-like	<359..>487	CDD:304874	103/127 (81%)
Mccc2	NP_001012177.1	PLN02820	36..563	CDD:178415	374/526 (71%)
		Carboxyltransferase. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01138	49..555		364/505 (72%)
		Acyl-CoA binding. /evidence=ECO:0000255	343..372		24/28 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340971
Domainoid	1	1.000	737	1.000	Domainoid score	I96
eggNOG	1	0.900	-	-		E1_COG4799
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11145
Inparanoid	1	1.050	775	1.000	Inparanoid score	I506
OMA	1	1.010	-	-		QHG62385
OrthoDB	1	1.010	-	-		D194285at33208
OrthoFinder	1	1.000	-	-		FOG0004920
OrthoInspector	1	1.000	-	-		oto96309
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22855
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4587
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870