DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tgs1 and TGS1

DIOPT Version :10

Sequence 1:NP_732316.2 Gene:Tgs1 / 59260 FlyBaseID:FBgn0266195 Length:466 Species:Drosophila melanogaster
Sequence 2:NP_079107.6 Gene:TGS1 / 96764 HGNCID:17843 Length:853 Species:Homo sapiens


Alignment Length:667 Identity:181/667 - (27%)
Similarity:263/667 - (39%) Gaps:274/667 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 WKEFWQREGHELLEQKWHKRFPEYKDLIEVVSSEEQGLW-----QELWEKHASDYSEKFWYIFSC 100
            |:::|...|..||.|.|.::.|.     :.:|||.   |     :|.||:|   ||:.:||.   
Human   198 WEKYWNEYGGGLLWQSWQEKHPG-----QALSSEP---WNFPDTKEEWEQH---YSQLYWYY--- 248

  Fly   101 AFENYQHDLAKSFGLDVAENSE------------------------------------------- 122
             .|.:|:..|:.:..|.:::.:                                           
Human   249 -LEQFQYWEAQGWTFDASQSCDTDTYTSKTEADDKNDEKCMKVDLVSFPSSPIMVDNDSSGTSDK 312

  Fly   123 ---DVEEDLQNLSLTNKPIKSKQ----------QRVTE--------------------KEEDESY 154
               ::.:.:.|:.|.::.:...|          |:::|                    .||..|.
Human   313 DHSEILDGISNIKLNSEEVTQSQLDSCTSHDGHQQLSEVSSKRECPASGQSEPRNGGTNEESNSS 377

  Fly   155 LTANDDP-----------------------------EDCDEEQQLRLL----------------- 173
            ...|.||                             ||..|.:..:|.                 
Human   378 GNTNTDPPAEDSQKSSGANTSKDRPHASGTDGDESEEDPPEHKPSKLKRSHELDIDENPASDFDD 442

  Fly   174 ----------------GLPT-----------------------------------------SFAS 181
                            |:|.                                         .|..
Human   443 SGSLLGFKYGSGQKYGGIPNFSHRQVRYLEKNVKLKSKYLDMRRQIKMKNKHIFFTKESEKPFFK 507

  Fly   182 KADI----------INYRKERKTQYELS----------SSDSEDD-------HDLLTMENNENEA 219
            |:.|          :|...:.:...|.|          |||||:.       .|||...|.|.|.
Human   508 KSKILSKVEKFLTWVNKPMDEEASQESSSHDNVHDASTSSDSEEQDMSVKKGDDLLETNNPEPEK 572

  Fly   220 LHGVQS--------------------------------------GSVKKKKRRQRQIKKLKARMP 246
            ...|.|                                      ..|||||.:::. ||:....|
Human   573 CQSVSSAGELETENYERDSLLATVPDEQDCVTQEVPDSRQAETEAEVKKKKNKKKN-KKVNGLPP 636

  Fly   247 ECMQEDNNKMVKYWVKRFSLFSRFDQGIRLDRESWFSVTPEKIAKQTARRLA----CDVIVDAFC 307
            |.....  ::.|||.:|:.||||||.||:||||.||||||||||:..|.|::    |||:|||||
Human   637 EIAAVP--ELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSFKCDVVVDAFC 699

  Fly   308 GCGGNAIQFANTCGRVIAVDIDAEKLAMAKHNAGIYGVAHKIEFIHADFLQFAASTKLRPNVVFL 372
            |.|||.||||.|..||||:|||..|:|:|::||.:||:|.|||||..|||..|:.  |:.:||||
Human   700 GVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASF--LKADVVFL 762

  Fly   373 SPPWGGPDYQKQATFDIETGLLPVGASQLMQLSRSLASDVAFFLPRNANMKQVVALSGVGQQCEV 437
            |||||||||....||||.|.:.|.| .::.:||:.:.:::.:||||||::.||.:|:|.|.|.|:
Human   763 SPPWGGPDYATAETFDIRTMMSPDG-FEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEI 826

  Fly   438 EHNYLDTRMVALTAYYG 454
            |.|:|:.::..:|||:|
Human   827 EQNFLNNKLKTITAYFG 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tgs1NP_732316.2 AdoMet_MTases 299..455 CDD:473071 84/156 (54%)
TGS1NP_079107.6 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 53..80
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..187
MSCRAMM_ClfA <263..445 CDD:468110 16/181 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 334..461 14/126 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 527..632 22/105 (21%)
Sufficient for catalytic activity 631..846 114/218 (52%)
AdoMet_MTases 691..843 CDD:473071 83/154 (54%)
Blue background indicates that the domain is not in the aligned region.

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