DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tgs1 and TGS1

DIOPT Version :9

Sequence 1:NP_732316.2 Gene:Tgs1 / 59260 FlyBaseID:FBgn0266195 Length:466 Species:Drosophila melanogaster
Sequence 2:NP_079107.6 Gene:TGS1 / 96764 HGNCID:17843 Length:853 Species:Homo sapiens


Alignment Length:667 Identity:181/667 - (27%)
Similarity:263/667 - (39%) Gaps:274/667 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 WKEFWQREGHELLEQKWHKRFPEYKDLIEVVSSEEQGLW-----QELWEKHASDYSEKFWYIFSC 100
            |:::|...|..||.|.|.::.|.     :.:|||.   |     :|.||:|   ||:.:||.   
Human   198 WEKYWNEYGGGLLWQSWQEKHPG-----QALSSEP---WNFPDTKEEWEQH---YSQLYWYY--- 248

  Fly   101 AFENYQHDLAKSFGLDVAENSE------------------------------------------- 122
             .|.:|:..|:.:..|.:::.:                                           
Human   249 -LEQFQYWEAQGWTFDASQSCDTDTYTSKTEADDKNDEKCMKVDLVSFPSSPIMVDNDSSGTSDK 312

  Fly   123 ---DVEEDLQNLSLTNKPIKSKQ----------QRVTE--------------------KEEDESY 154
               ::.:.:.|:.|.::.:...|          |:::|                    .||..|.
Human   313 DHSEILDGISNIKLNSEEVTQSQLDSCTSHDGHQQLSEVSSKRECPASGQSEPRNGGTNEESNSS 377

  Fly   155 LTANDDP-----------------------------EDCDEEQQLRLL----------------- 173
            ...|.||                             ||..|.:..:|.                 
Human   378 GNTNTDPPAEDSQKSSGANTSKDRPHASGTDGDESEEDPPEHKPSKLKRSHELDIDENPASDFDD 442

  Fly   174 ----------------GLPT-----------------------------------------SFAS 181
                            |:|.                                         .|..
Human   443 SGSLLGFKYGSGQKYGGIPNFSHRQVRYLEKNVKLKSKYLDMRRQIKMKNKHIFFTKESEKPFFK 507

  Fly   182 KADI----------INYRKERKTQYELS----------SSDSEDD-------HDLLTMENNENEA 219
            |:.|          :|...:.:...|.|          |||||:.       .|||...|.|.|.
Human   508 KSKILSKVEKFLTWVNKPMDEEASQESSSHDNVHDASTSSDSEEQDMSVKKGDDLLETNNPEPEK 572

  Fly   220 LHGVQS--------------------------------------GSVKKKKRRQRQIKKLKARMP 246
            ...|.|                                      ..|||||.:::. ||:....|
Human   573 CQSVSSAGELETENYERDSLLATVPDEQDCVTQEVPDSRQAETEAEVKKKKNKKKN-KKVNGLPP 636

  Fly   247 ECMQEDNNKMVKYWVKRFSLFSRFDQGIRLDRESWFSVTPEKIAKQTARRLA----CDVIVDAFC 307
            |.....  ::.|||.:|:.||||||.||:||||.||||||||||:..|.|::    |||:|||||
Human   637 EIAAVP--ELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSFKCDVVVDAFC 699

  Fly   308 GCGGNAIQFANTCGRVIAVDIDAEKLAMAKHNAGIYGVAHKIEFIHADFLQFAASTKLRPNVVFL 372
            |.|||.||||.|..||||:|||..|:|:|::||.:||:|.|||||..|||..|:.  |:.:||||
Human   700 GVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASF--LKADVVFL 762

  Fly   373 SPPWGGPDYQKQATFDIETGLLPVGASQLMQLSRSLASDVAFFLPRNANMKQVVALSGVGQQCEV 437
            |||||||||....||||.|.:.|.| .::.:||:.:.:::.:||||||::.||.:|:|.|.|.|:
Human   763 SPPWGGPDYATAETFDIRTMMSPDG-FEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEI 826

  Fly   438 EHNYLDTRMVALTAYYG 454
            |.|:|:.::..:|||:|
Human   827 EQNFLNNKLKTITAYFG 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tgs1NP_732316.2 Methyltransf_15 299..455 CDD:286524 84/156 (54%)
TGS1NP_079107.6 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 53..80
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..187
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 334..461 14/126 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 527..632 22/105 (21%)
Sufficient for catalytic activity 631..846 114/218 (52%)
Methyltransf_15 691..843 CDD:286524 83/154 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148519
Domainoid 1 1.000 170 1.000 Domainoid score I3798
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002744
OrthoInspector 1 1.000 - - oto89425
orthoMCL 1 0.900 - - OOG6_102135
Panther 1 1.100 - - LDO PTHR14741
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1507
SonicParanoid 1 1.000 - - X2121
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.870

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