DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RB1 and Rbf2

DIOPT Version :9

Sequence 1:	NP_000312.2	Gene:	RB1 / 5925	HGNCID:	9884	Length:	928	Species:	Homo sapiens
Sequence 2:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	893	Identity:	186/893 - (20%)
Similarity:	348/893 - (38%)	Gaps:	262/893 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    51 ETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEM-- 113
            ||....|:..|::|::...:::.|..|:.::.:|:|:  ...:...:.|..|...:.:...:|
  Fly    11 ETLVRRFSVSCEQLELEARIQQSALSTYHRLDAVNGL--STSEADAQEWLCCAVYSELQRSKMRD 73

Human   114 ------------------SFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAM------------ 148
                              :.:.|.|.::.:::|.:|...::..:..|:.:|..
  Fly    74 IRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELRCRLG 138

Human   149 --SRLLKKYDVLF-ALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQME- 209
              |.||:.|..:| :||....:..:      |.::...:    .:.:..|:.||:.:.|:....
  Fly   139 ITSTLLRHYKHIFRSLFVHPGKGAD------PGAANHYQ----ALYEFGWLLFLVIRNELPGFAI 193

Human   210 DDLVISFQLMLCVLD-YFIKLSP------------------------PMLLKEPYKTAVIPINGS 249
            .:|:...|:::|.:| .|:....                        |:||.   |.:|:...|.
  Fly   194 TNLINGCQVLVCTMDLLFVNALEVPRSVVIRREFSGVPKNWDTEDFNPILLN---KYSVLEALGE 255

Human   250 --PRTPRRG--QNRSARIAKQL----------ENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM 300
              |..|.:|  |.::|...|.|          .:||.:.|:: ||
  Fly   256 LIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREII-KE-------------------- 299

Human   301 NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQT--DSIDS----FETQRTPRK 359
               |::..|    :|||:::|........::|.|:.|.....::|  ||..|    |:|..:|..
  Fly   300 ---GMLDIN----LENLNRKYTNQVADISEMDERVLLSVQGAIETKGDSPKSPQLAFQTSSSPSH 357

Human   360 SNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGY 424
            ..|  ..:.:|...|          |.:|......:.::.:::|.:........:....|||
  Fly   358 RKL--STHDLPASLP----------LSIIKAFPKKEDADKIVNYLDQTLEEMNRTFTMAVKD--- 407

Human   425 IFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLAC 489
                 |..|      |:..:|::....|||:.::.:|..|..:.......:|:.......:||||
  Fly   408 -----FLDA------ELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLAC 461

Human   490 ALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAE-GNLTREMIKHLERC 553
            .||:.:..:.:     |..|  |.||::|:..:|.|:||.|::|..::.: |.|.||:||||:..
  Fly   462 CLELALHVHHK-----LVEG--LRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDVV 519

Human   554 EHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGS 618
            |...::||.:...|.|:..:.|                                   |.|:.|
  Fly   520 EEMCLDSLIFRKSSQLWWELNQ-----------------------------------RLPRYK-- 547

Human   619 TTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCER--LLSEHPELEHIIW 681
                  ..:|||:....|       ||..|:..:|.|.||..||..||:.  |:...|:    ||
  Fly   548 ------EVDAETEDKENF-------STGSSICLRKFYGLANRRLLLLCKSLCLVDSFPQ----IW 595

Human   682 TLFQH--TLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLI 744
            .|.:|  ||::. .|:|:|||||:::|:::...:::.:.|.|.:|:..|:..||..:..::.|.:
  Fly   596 HLAEHSFTLESS-RLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSL 659

Human   745 KEEEYDSIIVFYNSVFMQRL-------------------KTNI----------------LQYAST 774
            ...:...||.|||||::|.:                   ::|:                :..:|.
  Fly   660 GNGQTADIITFYNSVYVQSMGNYGRHLECAQTRKSLEESQSNVGILTETTSNELSMRANISISSP 724

Human   775 RPPTL----SPIPHIPRSPYKFP----SSP--LRIPGGNIYISPLKSP 812
            .||.:    |...|.|.||...|    |||  .|....|..:..:|.|
  Fly   725 PPPRVCQSGSCSSHPPSSPAASPLSLQSSPNVKRAASSNDLMREIKRP 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RB1	NP_000312.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		DUF3452	114..225	CDD:371807	22/127 (17%)
		Pocket, binds T and E1A	373..771		99/437 (23%)
		Domain A	373..579		49/206 (24%)
		RB_A	373..573	CDD:366846	48/200 (24%)
		Spacer	580..639		7/58 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..632		6/21 (29%)
		Domain B	640..771		43/169 (25%)
		RB_B	646..765	CDD:366845	40/141 (28%)
		Interaction with LIMD1. /evidence=ECO:0000269\|PubMed:15542589	763..928		17/95 (18%)
		Rb_C	768..924	CDD:370194	16/71 (23%)
		Domain C, mediates interaction with E4F1. /evidence=ECO:0000269\|PubMed:10869426	771..928		16/52 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..928
		Bipartite nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P13405	860..876
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	22/136 (16%)
		RB_A	380..536	CDD:280101	44/176 (25%)
		CYCLIN	564..679	CDD:294043	40/119 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147369
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850