Protein Alignment Zwilch and ZWILCH

DIOPT Version :10

• Sequence 1: NP_733421.1
• Gene: Zwilch / 59247
• FlyBaseID: FBgn0061476
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_060445.3
• Gene: ZWILCH / 55055
• HGNCID: 25468
• Length: 591
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 139/687 - (20%)
• Similarity: 245/687 - (35%)
• Gaps: 228/687 - (33%)

  Fly    45 KIVLVFKEDRNGAVARLRTTPTRAAPKKEGSADLDLTG----SPLKDDCLVDAIADLSIDLQLDH 105
            :::..|.|::.|    :|..|.    ..|....:.|..    :|||:....:.|..:...:.|:.
Human    15 RLLQKFNEEKKG----IRKDPF----LYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEK 71

  Fly   106 SNPWKLEE---------EYQRG-------IPVDKARSIV---------CSEFLQL---AEGLGSV 142
            .....:||         ::..|       :||.|||.::         ....|::   ...|..:
Human    72 EETSHIEELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKINLPVTALPPL 136

  Fly   143 WFLCDGSDLGQTQLLQYEFNPTHFS-RGILSYQGVRPA---YLVTSQAL-----VRHHGKTP--- 195
            |..||.||...|..|..|...|:.| .||:.|.....|   |.|..:.|     .|||..|.
Human   137 WVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKNYSVNLENLKNLHKKRHHLSTVTSK 201

  Fly   196 -------------DETLIENSYQVNPHMRLRCSW------------TSSAALPLLVNLNDCDVAL 235
                         |:|:..:...:    .|..||            :|:|.|.:.|...:....|
Human   202 GFAQYELFKSSALDDTITASQTAI----ALDISWSPVDEILQIPPLSSTATLNIKVESGEPRGPL 262

  Fly   236 NHTFRVGDCGPLTQDFMNQLRILVYIREDIVSYHTDVKQGVSR--DPTYRCGSGIDMDELRESIN 298
            ||.:|             :|:.|:.:.:.:       :.||:.  :|       ::.....|.:.
Human   263 NHLYR-------------ELKFLLVLADGL-------RTGVTEWLEP-------LEAKSAVELVQ 300

  Fly   299 QTMTDVSGLIGRYSISNAEFDIEDV------VQRA-----KVRQLTDLTDKLW-ELLKCCHSYKD 351
            :.:.|::.|.|....:..:.::|.:      |.|:     |||...|..::|| ::.....||:|
Human   301 EFLNDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQD 365

  Fly   352 LKIAFSMLFQCAARCNI---VNTPTNKNRLAKIITELANRRLAMPCLSGAEPLELLLEIGLEKLY 413
            |...|:::.|...|.:|   :::.:| :.|:|:|.:..:..:....|||..|:::||||||:||.
Human   366 LVKCFTLIIQSLQRGDIQPWLHSGSN-SLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLK 429

  Fly   414 KDYEFIYTESKMCSTNLLKDDSSGASMDDGSPQNLPQLRKSLHNAVRGDPTPGAGMRKTLLHH-- 476
            |||...:...::.|.|.| :.....|:|         :::.::             |...|||
Human   430 KDYISFFIGQELASLNHL-EYFIAPSVD---------IQEQVY-------------RVQKLHHIL 471

  Fly   477 -------------HGAVNSRS---TKYAGSDDDAGFKNSHFDEHESTERISKLFQIHCTLEHLLM 525
                         |..:.|.:   .||        :|.:..||                 :|:..
Human   472 EILVSCMPFIKSQHELLFSLTQICIKY--------YKQNPLDE-----------------QHIFQ 511

  Fly   526 MHIH-LNLANVYNDVCSELLKKPPKLVESIDD---------QLSDVMDIRLSAHYVRDHLDGKDP 580
            :.:. ..:.|:|..      :||.|....|..         ||||...|        |||:...|
Human   512 LPVRPTAVKNLYQS------EKPQKWRVEIYSGQKKIKTVWQLSDSSPI--------DHLNFHKP 562

  Fly   581 YSRHITMRSHNKFRELKTTFYFNSENICPPNLAQCFQ 617
            ....:|:..     .|:...:|.       |:..|.|
Human   563 DFSELTLNG-----SLEERIFFT-------NMVTCSQ 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zwilch	NP_733421.1	Zwilch	29..627	CDD:401684	139/687 (20%)
ZWILCH	NP_060445.3	Zwilch	31..573	CDD:401684	130/644 (20%)