DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18530 and LIPF

DIOPT Version :9

Sequence 1:	NP_652714.2	Gene:	CG18530 / 59241	FlyBaseID:	FBgn0042207	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001185758.1	Gene:	LIPF / 8513	HGNCID:	6622	Length:	408	Species:	Homo sapiens

Alignment Length:	369	Identity:	118/369 - (31%)
Similarity:	188/369 - (50%)	Gaps:	27/369 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AEIIASHNYPVEIHTVVTRDGYLLNAFRIP----NSIYCEQSGTKPAVLFQHGMTASSDVFLVNG 82
            :::|....||.|.:.|||.|||:|...|||    ||   ..:|.:|.|..|||:.||:..::.|.
Human    46 SQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNS---GNTGQRPVVFLQHGLLASATNWISNL 107

  Fly    83 PRDALPFMLADACFDVWLSNSRGTRYSRRHVSLDPSDEDFWRFSWHEIGTEDVAAFIDYILGTTN 147
            |.::|.|:||||.:||||.||||..::||::...|...:||.||:.|:...|:.|.||:|:..|.
Human   108 PNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTG 172

  Fly   148 QSAVHYVGHSQGCTTLVVLLSMRPEYNQFVKTAILLGPPVFMGHTHTLGQIFLRTLIMSMPDCEF 212
            |..:||||||||.|...:..|..|...:.:||...|.|...:.:|.:     |...:..:|...|
Human   173 QKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKS-----LINKLRFVPQSLF 232

  Fly   213 MF---------HNRILNKILRRICGLFVVRVYCSTFFMIVNGKFSDHLNTSAIPLIAATLPAGVS 268
            .|         ||.....:...:|...::.:.||....|:.|..|.:.|||.:.:..:..|||.|
Human   233 KFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTS 297

  Fly   269 SRQPKHFIQLTDSGRFRPFDFGI-LRNLINYRSLTPPDYPLHNVRPL-TPVHIFYSDDDLSAAKE 331
            .:...|:.|...||:|:.:|:|. ::|.::|....||.|   ||..: .|:.::....||.|..:
Human   298 VQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYY---NVTAMNVPIAVWNGGKDLLADPQ 359

  Fly   332 DVENFATSLPEAVMHRISTPSWHHMDFVHSMTVANVINKPVIEI 375
            ||......||..:.|: ..|.::|:||:.:|.....:...::.:
Human   360 DVGLLLPKLPNLIYHK-EIPFYNHLDFIWAMDAPQEVYNDIVSM 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18530	NP_652714.2	PLN02872	22..377	CDD:215470	118/369 (32%)
CG18530	NP_652714.2	Abhydro_lipase	22..82	CDD:282003	24/63 (38%)
LIPF	NP_001185758.1	PLN02872	14..400	CDD:215470	118/365 (32%)
		Abhydro_lipase	45..107	CDD:282003	24/63 (38%)
		Abhydrolase_5	88..>211	CDD:289465	52/122 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860