DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18530 and Gm8978

DIOPT Version :9

Sequence 1:	NP_652714.2	Gene:	CG18530 / 59241	FlyBaseID:	FBgn0042207	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001310180.1	Gene:	Gm8978 / 668106	MGIID:	3647649	Length:	399	Species:	Mus musculus

Alignment Length:	398	Identity:	113/398 - (28%)
Similarity:	204/398 - (51%)	Gaps:	24/398 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KTLVILSVCTQIV----------NGITSAEIIASHNYPVEIHTVVTRDGYLLNAFRIPNSIYCEQ 58
            :|:.::.|..:|.          :.:..:|||....||.|.:.|||.|||:|...|||:......
Mouse     6 RTMCLIHVLGKIFCLIGQNKNPESNMNVSEIIKHWEYPSEEYEVVTDDGYILPINRIPHGKNNAN 70

  Fly    59 SGTKPAVLF-QHGMTASSDVFLVNGPRDALPFMLADACFDVWLSNSRGTRYSRRHVSLDPSDEDF 122
            |.....|:| .||:.:::.:::.|.|.::|.|:||||.:||||.|:||:..:::||:|:...::|
Mouse    71 STAPKMVVFCLHGLFSTAGIWVSNPPDNSLAFILADAGYDVWLGNNRGSTRAKKHVTLNTDSKEF 135

  Fly   123 WRFSWHEIGTEDVAAFIDYILGTTNQSAVHYVGHSQGCTTLVVL--LSMRPEYNQFVKTAILLGP 185
            |.||:.|:...|:.|.|.:||..|.|..::|.|||||  ||:.|  .:...|..:.:|.:||:.|
Mouse   136 WAFSYDEMIKYDLPAIIKFILEKTGQKQIYYTGHSQG--TLIALGAFATNQELAEKIKLSILIAP 198

  Fly   186 PVFMGHTHTLGQI---FLRTLIMSMPDCEFMFHNRILNKILRRICGLFVVRVYCSTFFMIVNGKF 247
            ...:.:....|::   |..|....:...:..|..::.:::.:.:|.:.:|...|:|....:.|..
Mouse   199 VHTVKYVKGAGRLPAYFTPTAFKIVFGEKEFFPTKVFSRLSQHVCDIKLVDAGCATVLGSLTGYS 263

  Fly   248 SDHLNTSAIPLIAATLPAGVSSRQPK-HFIQLTDSGRFRPFDFGI-LRNLINYRSLTPPDYPLHN 310
            .:..|||.|. :..|...|.||.|.. |:.|...||.|:.:|:|. ..|:.:|...|||.|.:.:
Mouse   264 PEQFNTSRID-VYITHSLGESSIQILIHYGQAIRSGVFQAYDWGSPSLNMQHYNQTTPPVYNVED 327

  Fly   311 VRPLTPVHIFYSDDDLSAAKEDVENFATSLPEAVMHRISTPSWHHMDFVHSMTVANVINKPVIEI 375
            ::  .|..:|....|..:..|||.|....:.....|:|.: .:.|:||:..:.....:::.::.|
Mouse   328 MK--VPTAMFSGLKDFLSNPEDVANLVPKISNLTYHKIIS-DFSHLDFIMGLNARKEVSEEILTI 389

  Fly   376 FKRFEQPI 383
            .::::..|
Mouse   390 LRKYDGDI 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18530	NP_652714.2	PLN02872	22..377	CDD:215470	109/362 (30%)
CG18530	NP_652714.2	Abhydro_lipase	22..82	CDD:282003	21/60 (35%)
Gm8978	NP_001310180.1	PLN02872	17..391	CDD:215470	110/379 (29%)
		Abhydro_lipase	33..94	CDD:282003	21/60 (35%)
		Abhydrolase_5	77..242	CDD:289465	52/166 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831779
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960