Protein Alignment GstD10 and CLIC2

DIOPT Version :10

• Sequence 1: NP_652713.1
• Gene: GstD10 / 59240
• FlyBaseID: FBgn0042206
• Length: 210
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 53/227 - (23%)
• Similarity: 81/227 - (35%)
• Gaps: 82/227 - (36%)

  Fly     8 GSAP-CRSVLMTAKALGVEFDKKTIINTRAREQFTPEYLKINPQHTIPTLHDHGFALWESRAIMV 71
            |:.| |:.:.|.....||:|:..|:..||     .||.||.....|.|             ..:|
Human    28 GNCPFCQRLFMILWLKGVKFNVTTVDMTR-----KPEELKDLAPGTNP-------------PFLV 74

  Fly    72 YLVEKYGKDDKLFPKDVQKQALINQRL---------YFDMG-TLYKSFSEYYYPQIFLKKPANEE 126
            |  .|..|.|.:..::..:|.|...|.         .||:| .|:..||.|      :|....|.
Human    75 Y--NKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAY------IKNTQKEA 131

  Fly   127 N----------YKKIEVAFEFLNT--------------------FLEGQTYSAGGDYSLADIAFL 161
            |          :|:::   ::|||                    ||:|.      ..:|||.:.|
Human   132 NKNFEKSLLKEFKRLD---DYLNTPLLDEIDPDSAEEPPVSRRLFLDGD------QLTLADCSLL 187

  Fly   162 ATVSTFDVAG-----FDF-KRYANVARWYENA 187
            ..::...||.     ||. ..::.|.|:..||
Human   188 PKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNA 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstD10	NP_652713.1	GST_N_Delta_Epsilon	1..75	CDD:239343	18/67 (27%)
		GST_C_Delta_Epsilon	89..205	CDD:198287	32/145 (22%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		23/87 (26%)
		N-terminal	1..94		22/85 (26%)
		O-ClC	12..245	CDD:129941	53/227 (23%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		1/2 (50%)
		Joint loop	95..106		1/10 (10%)
		C-terminal	107..247		29/128 (23%)
		Foot loop	151..171		2/19 (11%)