DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZSCAN16

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001307484.1	Gene:	ZSCAN16 / 80345	HGNCID:	20813	Length:	348	Species:	Homo sapiens

Alignment Length:	356	Identity:	88/356 - (24%)
Similarity:	135/356 - (37%)	Gaps:	91/356 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 TQKQLVHRRR-------------SPEAKEPAEDVEEMASP---PDCLNDPFGEVDEYIVESPEEV 119
            :||...|||.             :|..:|....:.|:...   |:| :.....:|..::|....:
Human    29 SQKCSPHRRELYRQHFRKLCYQDAPGPREALTQLWELCRQWLRPEC-HTKEQILDLLVLEQFLSI 92

  Fly   120 LDHDSD----AHHDLDEDNYIDSVEDVDALQDMAEVAEEDSQDVESLISSVQKELESICNDDSNS 180
            |..|..    |||....:      |.|..|:|:....:|..:.|                 ..||
Human    93 LPKDLQAWVRAHHPETGE------EAVTVLEDLERELDEPGKQV-----------------PGNS 134

  Fly   181 DNNDYM------------------------------EPQNGSYFNETINEYEVSSNPNTPLPESK 215
            :..|.:                              :||.......|.|| |:....:  :|:.|
Human   135 ERRDILMDKLAPLGRPYESLTVQLHPKKTQLEQEAGKPQRNGDKTRTKNE-ELFQKED--MPKDK 196

  Fly   216 SAAG----RSTKPATTKPKRKKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLH 276
            ...|    |..|.....|| .|..:..:..:|.|..||:|.:      |::||:.|:..|:...|
Human   197 EFLGEINDRLNKDTPQHPK-SKDIIENEGRSEWQQRERRRYK------CDECGKSFSHSSDLSKH 254

  Fly   277 MLRHTGNKNFACQQCGKRF-YTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNA 340
            ...|||.|.:.|.:|||.| ...||:..|:  :|.|.|||.|:.|.|.|......:.|:|.||..
Human   255 RRTHTGEKPYKCDECGKAFIQRSHLIGHHR--VHTGVKPYKCKECGKDFSGRTGLIQHQRIHTGE 317

  Fly   341 KPYSCHHCDKCFKSASGRKRHELIHTGVRAF 371
            |||.|..|.:.|:.:|...||:.|||..:.:
Human   318 KPYECDECGRPFRVSSALIRHQRIHTANKLY 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	2/3 (67%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	10/25 (40%)
		C2H2 Zn finger	288..309	CDD:275368	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368
ZSCAN16	NP_001307484.1	SCAN	37..148	CDD:128708	22/134 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..184		3/23 (13%)
		COG5048	<183..323	CDD:227381	50/151 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..226		5/21 (24%)
		C2H2 Zn finger	238..258	CDD:275368	6/19 (32%)
		C2H2 Zn finger	266..286	CDD:275368	8/21 (38%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		zf-C2H2	320..342	CDD:306579	7/21 (33%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050