DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZNF557

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001037852.1	Gene:	ZNF557 / 79230	HGNCID:	28632	Length:	430	Species:	Homo sapiens

Alignment Length:	310	Identity:	83/310 - (26%)
Similarity:	128/310 - (41%)	Gaps:	81/310 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 EDNYIDSVEDVDALQDMA------EVAEEDSQDVES---------LISSVQKE----------LE 171
            ||..::..::..||.|.|      :|..|:.:::.|         |||.:::|          |.
Human    46 EDVAVEFTQEEWALLDPAQRTLYRDVMLENCRNLASLGNQVDKPRLISQLEQEDKVMTEERGILS 110

  Fly   172 SICNDDSN-----------------SDNNDYMEPQN-GSYFNETINEYEVSSNPNTPLPESKSAA 218
            ..|.|..|                 ...|..||..: |:..||....::|.
Human   111 GTCPDVENPFKAKGLTPKLHVFRKEQSRNMKMERNHLGATLNECNQCFKVF-------------- 161

  Fly   219 GRSTKPATTKPKRKKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGN 283
              |||.:.|:                   .||....:|...|.:||:.::.:|...:|...|.|.
Human   162 --STKSSLTR-------------------HRKIHTGERPYGCSECGKSYSSRSYLAVHKRIHNGE 205

  Fly   284 KNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHC 348
            |.:.|..|||.|.:...:|:|:| ||.|||||:|..|.|:|.||:....|.|.||..|||.|:.|
Human   206 KPYECNDCGKTFSSRSYLTVHKR-IHNGEKPYECSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQC 269

  Fly   349 DKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAK 398
            .:.|::.|...||:.:|||...:.|..|.::|...:.|.:|.  ..||.:
Human   270 FREFRTQSIFTRHKRVHTGEGHYVCNQCGKAFGTRSSLSSHY--SIHTGE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	272..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	5/17 (29%)
ZNF557	NP_001037852.1	KRAB	43..100	CDD:214630	13/53 (25%)
		KRAB	43..82	CDD:279668	8/35 (23%)
		COG5048	<137..422	CDD:227381	66/219 (30%)
		C2H2 Zn finger	154..174	CDD:275368	7/54 (13%)
		C2H2 Zn finger	182..202	CDD:275368	5/19 (26%)
		zf-H2C2_2	194..219	CDD:290200	9/24 (38%)
		C2H2 Zn finger	210..230	CDD:275368	8/20 (40%)
		zf-H2C2_2	222..247	CDD:290200	14/25 (56%)
		C2H2 Zn finger	238..258	CDD:275368	8/19 (42%)
		zf-H2C2_2	254..275	CDD:290200	10/20 (50%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	5/21 (24%)
		zf-C2H2	320..342	CDD:278523
		C2H2 Zn finger	322..342	CDD:275368
		zf-H2C2_2	334..359	CDD:290200
		C2H2 Zn finger	350..370	CDD:275368
		zf-H2C2_2	362..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		zf-H2C2_2	390..415	CDD:290200
		C2H2 Zn finger	406..426	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960