DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZNF213

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001128127.1	Gene:	ZNF213 / 7760	HGNCID:	13005	Length:	459	Species:	Homo sapiens

Alignment Length:	363	Identity:	95/363 - (26%)
Similarity:	133/363 - (36%)	Gaps:	96/363 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VHRRRSPEAKEPAEDVEEMASPPDCLND-------------------PFGEVDEYIVESPEEVLD 121
            |..||.|..  |.|.....|.||..|.:                   ..|::..|........||
Human   158 VGARRRPSV--PQEQHSHSAQPPALLKEGRPGETTDTCFVSGVHGPVALGDIPFYFSREEWGTLD 220

  Fly   122 HDSDAHHDLDEDNYIDSVEDVDALQDMAEVAEEDS-----------QDVESLISSVQKELESICN 175
               .|..||..|                 :..|:|           |..:||:    :|:..:..
Human   221 ---PAQRDLFWD-----------------IKRENSRNTTLGFGLKGQSEKSLL----QEMVPVVP 261

  Fly   176 DDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLPESKSAAG-----RSTKPATTKPKRKKQY 235
            ..:.||......|:          |.|...:.|.|    ::|.|     |..:|    |.|::|:
Human   262 GQTGSDVTVSWSPE----------EAEAWESENRP----RAALGPVVGARRGRP----PTRRRQF 308

  Fly   236 VTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFYTDHL 300
                          :.|..::...|.|||::|...|:...|...|||.|...|.:|.|.|.:...
Human   309 --------------RDLAAEKPHSCGQCGKRFRWGSDLARHQRTHTGEKPHKCPECDKSFRSSSD 359

  Fly   301 MTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRHELIH 365
            :..||. :|.||||:.|..|.|||..|.....|:|.||..||:.|..|.|.|...|....|..:|
Human   360 LVRHQG-VHTGEKPFSCSECGKSFSRSAYLADHQRIHTGEKPFGCSDCGKSFSLRSYLLDHRRVH 423

  Fly   366 TGVRAFACTICKQSFQRNTHLKAHLRSKFHTAKAKTIG 403
            ||.|.|.|..|.:||::..||.||  ...|...|:.:|
Human   424 TGERPFGCGECDKSFKQRAHLIAH--QSLHAKMAQPVG 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	288..309	CDD:275368	6/20 (30%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	8/17 (47%)
ZNF213	NP_001128127.1	SCAN	41..145	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..188		10/31 (32%)
		KRAB_A-box	202..237	CDD:143639	10/54 (19%)
		COG5048	<315..451	CDD:227381	53/138 (38%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	347..367	CDD:275368	6/20 (30%)
		C2H2 Zn finger	375..395	CDD:275368	8/19 (42%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..451	CDD:275368	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050