DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZKSCAN8

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001265048.1	Gene:	ZKSCAN8 / 7745	HGNCID:	12983	Length:	578	Species:	Homo sapiens

Alignment Length:	367	Identity:	95/367 - (25%)
Similarity:	142/367 - (38%)	Gaps:	100/367 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 EDVEEMASP---PDCLNDPFGEVDEYIVESPEEVLDHDSDAHHDLDEDNYIDSVEDVDAL--QDM 148
            |.:|:||..   .:.|.||                     :..||..||..::..::.:|  :..
Human   220 EKIEDMAVSLIREEWLLDP---------------------SQKDLCRDNRPENFRNMFSLGGETR 263

  Fly   149 AEVAEEDSQDVESLISSVQKELESICNDD-----SNSDNNDY---MEPQNGSYFNETINEYEVSS 205
            :|..|..|:.|.|.......|..:.||.|     .:.:..|.   :|.|.|
Human   264 SENRELASKQVISTGIQPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRG-------------- 314

  Fly   206 NPNTPLPESKSAAGRSTKPATTKPKRKKQYVTWKNMTEEQ----------------IIERKRLQR 254
            ||...........|:|...::...:.      |:..|.|:                ::..:.:..
Human   315 NPTQERRHKCDECGKSFAQSSGLVRH------WRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHN 373

  Fly   255 K-RECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRI----------- 307
            | :...|::||:.|:..:...||...|||.|.:.|.||||.|.....:.|||||
Human   374 KVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNE 438

  Fly   308 ----------------IHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSAS 356
                            ||.|||||:|..|.|:|..|:..:.|:|:||..|||.|:.|.:.|...|
Human   439 CGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKS 503

  Fly   357 GRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAK 398
            |...|:.||||.|.:.|..|.::|..||.|..|||  .||.:
Human   504 GLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLR--IHTGE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	12/24 (50%)
		C2H2 Zn finger	288..309	CDD:275368	11/47 (23%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	7/17 (41%)
ZKSCAN8	NP_001265048.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SCAN	47..159	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..205
		KRAB_A-box	221..>262	CDD:322003	11/61 (18%)
		COG5048	<315..564	CDD:227381	70/237 (30%)
		C2H2 Zn finger	324..344	CDD:275368	3/25 (12%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	10/19 (53%)
		C2H2 Zn finger	436..456	CDD:275368	0/19 (0%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	9/21 (43%)
		C2H2 Zn finger	548..568	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960