Protein Alignment CG18764 and ZNF649

DIOPT Version :9

• Sequence 1: NP_652712.2
• Gene: CG18764 / 59239
• FlyBaseID: FBgn0042205
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_075562.2
• Gene: ZNF649 / 65251
• HGNCID: 25741
• Length: 505
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 90/341 - (26%)
• Similarity: 141/341 - (41%)
• Gaps: 72/341 - (21%)

  Fly    81 SPEAKEPAED-----------VEEMASPPDCL-----NDPFGEVDEYIVESPEEVLDHDSDAHHD 129
            ||..|:...|           |...|..||.|     .:|...:::.|          .|.||.:
Human    26 SPAQKDLYRDVMLENYSNLVSVGYQAGKPDALTKLEQGEPLWTLEDEI----------HSPAHPE 80

  Fly   130 LDE-DNYIDSVEDVDALQDMAEVAEEDSQDVESLISSVQKELESICNDDSNSDNNDYMEPQ---- 189
            ::: |:::.     ..||:. ::.:...|..|.     .:.|:|.....:.|...:..||.
Human    81 IEKADDHLQ-----QPLQNQ-KILKRTGQRYEH-----GRTLKSYLGLTNQSRRYNRKEPAEFNG 134

  Fly   190 NGSYFNETINEYEVSSNPNTPLPESKSAAGRSTKPATTKPKRKKQYVTWKNMTEEQIIERKRLQR 254
            :|::.::  |..::.:  ....|||:       ||.:||.:..|...|            ..:::
Human   135 DGAFLHD--NHEQMPT--EIEFPESR-------KPISTKSQFLKHQQT------------HNIEK 176

  Fly   255 KRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRF 319
            ..||.  .||:.|..:|....|...|||.|...|..|||.||..:.:|.|:| .|:||||:.|..
Human   177 AHECT--DCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHER-AHRGEKPHGCSL 238

  Fly   320 CTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNT 384
            |.|:|:.......|||.|...|||.|..|.|.|...|....|:.||||::...|:.|.::|.|.:
Human   239 CGKAFYKRYRLTEHERAHKGEKPYGCSECGKAFPRKSELTEHQRIHTGIKPHQCSECGRAFSRKS 303

  Fly   385 ----HLKAHLRSKFHT 396
                |.:.|...|.||
Human   304 LLVVHQRTHTGEKPHT 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	272..297	CDD:290200	10/24 (42%)
		C2H2 Zn finger	288..309	CDD:275368	9/20 (45%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	6/21 (29%)
ZNF649	NP_075562.2	KRAB	8..68	CDD:214630	10/41 (24%)
		KRAB	8..47	CDD:279668	4/20 (20%)
		C2H2 Zn finger	180..200	CDD:275368	6/21 (29%)
		zf-H2C2_2	193..215	CDD:290200	9/21 (43%)
		C2H2 Zn finger	208..228	CDD:275368	9/20 (45%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		COG5048	260..>321	CDD:227381	22/60 (37%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	276..301	CDD:290200	8/24 (33%)
		C2H2 Zn finger	292..312	CDD:275368	5/19 (26%)
		zf-H2C2_2	305..329	CDD:290200	5/15 (33%)
		C2H2 Zn finger	320..340	CDD:275368	90/341 (26%)
		zf-H2C2_2	332..357	CDD:290200
		C2H2 Zn finger	348..368	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368
		zf-H2C2_2	389..413	CDD:290200
		C2H2 Zn finger	404..424	CDD:275368
		C2H2 Zn finger	432..452	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..481

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050