DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	386	Identity:	108/386 - (27%)
Similarity:	162/386 - (41%)	Gaps:	84/386 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ERCILTQKQL------VHRRRSPEAKEPAEDVEEM-------ASPPDCLNDPF----------GE 107
            |:|....|.|      |.|.|.|   ||....|||       ||.|...:|..          ||
Human   304 EQCRTKFKSLQLSYRKVRRGRVP---EPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGE 365

  Fly   108 VDEYIVESPEEVLDHDSDAHHDLDEDNYIDSVEDVDALQDMA-------------EVAEE----- 154
            ::....| |.||.|...|. .|.||.::.:..::|..| |:.             |:.:|
Human   366 LNHQNGE-PTEVEDGTVDG-ADRDEKDFRNPGQEVRKL-DLPVLFPNRLGFEFKNEIKKENLKWD 427

  Fly   155 DSQDVESLISSVQKELESICNDDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLPESKSAAG 219
            ||::||     :.|.|:               ....|.|::..:.: .:.|.| |...:.:::.|
Human   428 DSEEVE-----INKALQ---------------RKSRGVYWHSELQK-GLESEP-TSRRQCRNSPG 470

  Fly   220 RSTKPATTKPKRKKQ-----------YVTWKNMTEEQIIERK-RLQRKRECVCEQCGRQFTDQSN 272
            .|.:...::.|...|           .:..||.::......| .|:.::...|.:||:.|:..|.
Human   471 ESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSY 535

  Fly   273 FKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTH 337
            ...|...|||.|...|.:|||.|.....:|.|.| .|.||:||.|..|.|||:.|::.::|:|||
Human   536 LVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLR-THTGERPYQCGQCGKSFNQSSSLIVHQRTH 599

  Fly   338 TNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAK 398
            |..|||.|..|.|.|.::|....|..||||...:.|.:|.:.|..::|..||  .|.||.:
Human   600 TGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAH--RKTHTGE 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	3/8 (38%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	10/24 (42%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549	10/32 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		5/32 (16%)
		COG5048	<455..668	CDD:227381	67/208 (32%)
		zf-C2H2	522..543	CDD:278523	6/20 (30%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)
		zf-H2C2_2	535..559	CDD:290200	9/23 (39%)
		C2H2 Zn finger	551..571	CDD:275368	8/20 (40%)
		zf-H2C2_2	563..588	CDD:290200	13/25 (52%)
		C2H2 Zn finger	579..599	CDD:275368	8/19 (42%)
		zf-H2C2_2	591..616	CDD:290200	12/24 (50%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	8/20 (40%)
		C2H2 Zn finger	635..655	CDD:275368	7/21 (33%)
		zf-H2C2_2	647..671	CDD:290200	6/14 (43%)
		zf-C2H2	661..683	CDD:278523
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960