DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and CG31365

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	626	Identity:	126/626 - (20%)
Similarity:	199/626 - (31%)	Gaps:	237/626 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALQCRTCGSIIYNKMPKNLFHIENEKMLQDINLVTGTTLHNDPE----LPSSICACCTLDLNQA 61
            :|..||.|  :..::....:|..::.::...:.|:....|  |.:    ||..||..|...|.::
  Fly    10 LATLCRLC--LKEHQDAYAIFDEDDTQLSIPVRLMACVAL--DAKATDTLPKRICQECRYQLEKS 70

  Fly    62 ILFRERCILTQKQL--------------------------------------------------- 75
            .|||:||...:|:|
  Fly    71 FLFRQRCQWAEKKLRKHIRLLGLGKRSRVFSKDPDDYDEDELEFEDSIAFIEVQDKVRKLEDEKW 135

  Fly    76 -----------VHRR------------------------RSPEAKEPAEDVEEMASPPDCLNDP- 104
                       :|:|                        ||...||.||:|..... .|..|:.
  Fly   136 REDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQVR-DDLRNEVS 199

  Fly   105 -----------FGEVDEYIVE------------SPE------------------------EVLDH 122
                       .||::.|:.|            .||                        .::|.
  Fly   200 EDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDA 264

  Fly   123 D---SDAHHDLDEDNYI---------DSVEDVDALQDMAEVAEEDSQDVESLISSVQKE------ 169
            :   ::|..|..|:.:|         :|..::|.|:...||..|..:|... |:.|..:
  Fly   265 NLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFRE-INMVGSDVVHTDN 328

  Fly   170 -----LESICNDDSNSDNNDYMEPQNG--SY-----------------------FN---ETINEY 201
                 :.|..::|.|.|:....:..||  ||                       ||   |...|.
  Fly   329 GEIYIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQEQ 393

  Fly   202 EVSS---------------NPNTPLPESKSA--------------AGRSTKPATTKPKR----KK 233
            :|.|               :..|||...:|:              .||.|.  |.|..:    ..
  Fly   394 QVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITD--TVKSFQCHLCPV 456

  Fly   234 QYVTWKNMTEEQIIERKRLQRKR--ECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFY 296
            .:.|.|.:|.......|.|:..:  ...|..|..|.:..|:.|.||:.|||.|.|.|.:|...|.
  Fly   457 AFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFS 521

  Fly   297 TDHLMTLHQRIIHQGEKPYDCRFCTKSF-HNSNTRLIHERTHT-NAKPYSCHHCDKCFKSASGRK 359
            ...::..|.. .|.|.|.:.|..|:..| ..||.:....|.|. |::.:.||.|.:.|...||..
  Fly   522 QREVLKRHMD-THTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLS 585

  Fly   360 RHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAKAK 400
            ||.:.|.|| .|:|..|.:.|...:.::.|: :..|..|.|
  Fly   586 RHLVTHAGV-MFSCKQCGRQFNDRSAVQRHV-TTMHKVKNK 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	19/74 (26%)
		C2H2 Zn finger	260..280	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..297	CDD:290200	11/24 (46%)
		C2H2 Zn finger	288..309	CDD:275368	4/20 (20%)
		C2H2 Zn finger	317..337	CDD:275368	6/20 (30%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..391	CDD:275368	4/17 (24%)
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	20/76 (26%)
		vATP-synt_E	109..>244	CDD:304907	17/135 (13%)
		RRF	<161..222	CDD:294170	13/61 (21%)
		zf-C2H2_8	454..530	CDD:292531	20/75 (27%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	4/20 (20%)
		zf-H2C2_2	526..550	CDD:290200	7/24 (29%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..617	CDD:275368	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050