DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and CG4424

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_650859.3	Gene:	CG4424 / 42390	FlyBaseID:	FBgn0038765	Length:	345	Species:	Drosophila melanogaster

Alignment Length:	425	Identity:	100/425 - (23%)
Similarity:	154/425 - (36%)	Gaps:	138/425 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALQCRTC-----GSIIYNKMPKNLFHIENEKMLQDINL------VTGTTLH---NDPELPSSIC 51
            |...||||     ..::      ::|...::::...::|      ::|..:.   .:..||:.||
  Fly     7 MMTLCRTCLQDGEAHMV------SIFQTADDRLPGGVSLCDKIESLSGIQIRATAKEEVLPTRIC 65

  Fly    52 ACCTLDLNQAILFRERCILTQKQLVHRRRSPE---------------AKEPAEDVEEMASPPDCL 101
            ..|...|..|..||:.|          :||.|               .||..:.......||
  Fly    66 LRCKAFLTLAHKFRQIC----------QRSNEFLREYVIKDAVEQGVVKEVVQQTRPSTPPP--- 117

  Fly   102 NDPFGEVDEYIVESPE-EVLDHDSDAHHDLDEDNYIDSVEDVDALQDMAEVAEEDSQDVESLISS 165
                  ::...:|.|| |||:                  |.|.:.:|..|         |:....
  Fly   118 ------IETEQLEPPEDEVLE------------------EGVWSTEDPIE---------ETPHGP 149

  Fly   166 VQKELESICNDDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLPESKSAAGRSTKPATTKPK 230
            .:||                         ..|:...|:...|..|             ||:|.|.
  Fly   150 AEKE-------------------------RPTVLTVEMLPAPYPP-------------PASTPPP 176

  Fly   231 RKKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRF 295
            .....|..|..                 ||..||..:..:|....||.||...:.:.|:.|.|.|
  Fly   177 APAGAVKGKLH-----------------VCAICGNGYPRKSTLDTHMRRHNDERPYECEICHKSF 224

  Fly   296 YTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKR 360
            :.::.:..|.| .|.|.|||.|::|.::|.:..:.:.|||||.|.:||:|..|.|.|..||..|.
  Fly   225 HVNYQLKRHIR-QHTGAKPYTCQYCQRNFADRTSLVKHERTHRNERPYACKTCGKKFTYASVLKM 288

  Fly   361 HELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFH 395
            |...|||.:...|.:|.:||.|..:|.|||:::.|
  Fly   289 HYKTHTGEKPHICQLCNKSFARIHNLVAHLQTQQH 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	17/84 (20%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	8/24 (33%)
		C2H2 Zn finger	288..309	CDD:275368	6/20 (30%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..391	CDD:275368	8/17 (47%)
CG4424	NP_650859.3	zf-AD	10..92	CDD:285071	20/97 (21%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		DUF45	<204..281	CDD:302795	29/77 (38%)
		COG5048	210..>345	CDD:227381	43/115 (37%)
		C2H2 Zn finger	217..237	CDD:275368	6/20 (30%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		zf-H2C2_2	257..282	CDD:290200	12/24 (50%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	9/23 (39%)
		C2H2 Zn finger	301..320	CDD:275368	9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960