DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and CG17806

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	131/451 - (29%)
Similarity:	193/451 - (42%)	Gaps:	97/451 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALQCRTCGSIIYNKMPKNLFHIENEKMLQDINLVTGTTLHNDPELPSSICACCTLDLNQAILFR 65
            |...|||||.  ..:..|:||..|...:|.:|..:||..|.|.|.:|:.||..|.||||.||.||
  Fly     1 MTTLCRTCGQ--EAEHAKSLFDKEARDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFR 63

  Fly    66 ERCILTQK-------------------------------------QLVHRRRSPEAKE-----PA 88
            ||||.|..                                     |...||..|:..:     |.
  Fly    64 ERCIRTNSSWFEKQGKQEDSDTETAREGGNNRLESRVDVMPISIAQPQRRRILPQRSKKVDGVPL 128

  Fly    89 EDVEEMASP---PDCLNDPFGEVDEYIVESPEEVLDHDSDAHHDLDEDNYIDSVEDVDALQDMAE 150
            :.||....|   |:.  .|...||....|.|.:|     .:...|..|..::|:...:...:|.:
  Fly   129 KTVETPIYPLVVPEI--PPADLVDPLRCEDPIQV-----KSEPQLSSDYPVESMNHEEPASEMPQ 186

  Fly   151 VAEEDSQDVESLISSVQKELESICNDDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLPESK 215
            |.:|:.:.:: :|..|||               :..:|::.....|.               ..|
  Fly   187 VMKEEPRTLQ-VIGEVQK---------------NRRKPRSKGCLEEC---------------PGK 220

  Fly   216 SAAGRSTKPATTKPKRKKQYVT---WKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHM 277
            ..|......:||...::::|.|   |........:|.      |...|:|||:.|:::.||.:|:
  Fly   221 DMAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEH------RLYFCDQCGKTFSEKGNFNVHL 279

  Fly   278 LRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNA-- 340
            .||.|.|.|.||:|.:..:|.||:.||.||.|:||.||.|::|.|.|.|...||.|||.|..:
  Fly   280 RRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPV 344

  Fly   341 -KPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAKAK 400
             :|:.|..|.|.||:::..|.|.::|||.:.|.|.:|:..|.|...|..|.:||.|..|.:
  Fly   345 HRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKSKHHRLKVE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	33/107 (31%)
		C2H2 Zn finger	260..280	CDD:275368	8/19 (42%)
		zf-H2C2_2	272..297	CDD:290200	11/24 (46%)
		C2H2 Zn finger	288..309	CDD:275368	10/20 (50%)
		C2H2 Zn finger	317..337	CDD:275368	10/19 (53%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	33/73 (45%)
		zf-C2H2	260..282	CDD:278523	8/21 (38%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	10/20 (50%)
		COG5048	<298..>383	CDD:227381	37/84 (44%)
		C2H2 Zn finger	319..339	CDD:275368	10/19 (53%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		ZnF_U1	375..407	CDD:197732	11/31 (35%)
		C2H2 Zn finger	378..396	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450092
Domainoid	1	1.000	48	1.000	Domainoid score	I19075
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.790