DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and Zif

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	101/408 - (24%)
Similarity:	163/408 - (39%)	Gaps:	75/408 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CRTCGSIIYNKMPKNLFHIENE------KMLQDINLVTGTTLHNDPELPSSICACCTLDLNQAIL 63
            ||.|  :..::..:.|..|..|      :||..:..|:.:.|::...:|..||..|.::||.|..
  Fly    10 CRVC--LAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQ 72

  Fly    64 FRERCILTQKQLVHRRRSPEAKEPAEDVEEMASPPDCLNDPFGEVDEY------IVESPEEVLDH 122
            |||:.:  :||:                               |::||      :.||...::..
  Fly    73 FREKAL--RKQM-------------------------------EIEEYCRELGLLDESDVMMIKE 104

  Fly   123 DSDAHHDLDEDNYI-----DSVEDVDALQDMAEVAEEDSQDVESLISSVQKELESICNDDSNSDN 182
            :..:....||:.||     ...|:....:...|..|.|:.|.:..|....:.||.....:.|||.
  Fly   105 EDGSQQQCDEEMYILEETTTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQ 169

  Fly   183 NDYMEPQNGSYFNETINEYEVSSNPNTPLPESKSAAGRSTKPATTKPKRKKQYVTWKNMTEEQII 247
            .:.:        .|:..:||.:.:....|.|   ||..|.|....:.:|....:|..:.||
  Fly   170 TEIV--------LESEKQYEETPSQQLALQE---AAKASLKARRGRVRRGLNSLTTSDGTE---- 219

  Fly   248 ERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGE 312
                   |...:|:.||..:..:.....|..||.|...:||:.|..:|.....:..|. ..|.|.
  Fly   220 -------KGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHM-YSHTGS 276

  Fly   313 KPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICK 377
            |||.|.||::.|...:....||..|...|||.|..|||.|..|....:|||||:.::.:.|..|.
  Fly   277 KPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCN 341

  Fly   378 QSFQRNTHLKAHLRSKFH 395
            :.|:...|::.|..:|.|
  Fly   342 KDFRLLHHMRQHEETKLH 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	21/75 (28%)
		C2H2 Zn finger	260..280	CDD:275368	4/19 (21%)
		zf-H2C2_2	272..297	CDD:290200	8/24 (33%)
		C2H2 Zn finger	288..309	CDD:275368	4/20 (20%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	9/19 (47%)
		C2H2 Zn finger	373..391	CDD:275368	5/17 (29%)
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	23/111 (21%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		COG5048	<250..369	CDD:227381	38/111 (34%)
		C2H2 Zn finger	253..273	CDD:275368	4/20 (20%)
		zf-H2C2_2	266..288	CDD:290200	9/22 (41%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..353	CDD:275368	4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960