DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18764 and ZNF517

DIOPT Version :9

Sequence 1:NP_652712.2 Gene:CG18764 / 59239 FlyBaseID:FBgn0042205 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_001371833.1 Gene:ZNF517 / 340385 HGNCID:27984 Length:492 Species:Homo sapiens


Alignment Length:341 Identity:93/341 - (27%)
Similarity:138/341 - (40%) Gaps:69/341 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 MASPPDCLNDPFGEVDEYIVESPEEVLDHDSDA-HHDLDEDNY------------------IDSV 139
            |..|.:.:  .|.:|..|........|..|..| :.|:..:||                  ::..
Human     7 MPGPQEAV--VFEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGNLASLGFLVAKPALISLLEQG 69

  Fly   140 EDVDALQDMAEVAEEDSQDVESLISSVQKELESICNDDSNSDNNDYMEPQN----------GSYF 194
            |:..||  :.:|||:          ||.|  .|:|. ||..:......|..          |:.:
Human    70 EEPGAL--ILQVAEQ----------SVAK--ASLCT-DSRMEAGIMESPLQRKLSRQAGLPGTVW 119

  Fly   195 NETINEYEVSSNPNTPLPESKSAAGRSTKPATTKPKRKKQYVTWKNMTEEQIIERKRLQR----- 254
            ......:.|..:|..|.|......| |.||  |.|:.::...:.:.:.|:       |.|     
Human   120 GCLPWGHPVGGHPAPPHPHGGPEDG-SDKP--THPRAREHSASPRVLQED-------LGRPVGSS 174

  Fly   255 --KRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDC 317
              :..||   ||:.|...|....|.:.|||.|.|.|.:|||.|....::..|| :||..|||:.|
Human   175 APRYRCV---CGKAFRYNSLLLRHQIIHTGAKPFQCTECGKAFKQSSILLRHQ-LIHTEEKPFQC 235

  Fly   318 RFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQR 382
            ..|.|:|..|.....|.|.||..:||:|..|.|.|..:|...:|:..|||.:.||||.|.::|.|
Human   236 GECGKAFRQSTQLAAHHRVHTRERPYACGECGKAFSRSSRLLQHQKFHTGEKPFACTECGKAFCR 300

  Fly   383 NTHLKAHLRSKFHTAK 398
            ...|..|  .:.|:.:
Human   301 RFTLNEH--GRIHSGE 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18764NP_652712.2 zf-AD 4..75 CDD:214871
C2H2 Zn finger 260..280 CDD:275368 5/19 (26%)
zf-H2C2_2 272..297 CDD:290200 11/24 (46%)
C2H2 Zn finger 288..309 CDD:275368 7/20 (35%)
C2H2 Zn finger 317..337 CDD:275368 7/19 (37%)
C2H2 Zn finger 345..365 CDD:275368 6/19 (32%)
C2H2 Zn finger 373..391 CDD:275368 7/17 (41%)
ZNF517NP_001371833.1 KRAB 14..73 CDD:214630 10/60 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..170 11/50 (22%)
C2H2 Zn finger 180..199 CDD:275368 7/21 (33%)
COG5048 <203..342 CDD:227381 44/115 (38%)
C2H2 Zn finger 207..227 CDD:275368 7/20 (35%)
C2H2 Zn finger 235..255 CDD:275368 7/19 (37%)
C2H2 Zn finger 263..283 CDD:275368 6/19 (32%)
COG5048 <287..459 CDD:227381 10/30 (33%)
C2H2 Zn finger 291..311 CDD:275368 7/21 (33%)
C2H2 Zn finger 319..339 CDD:275368
C2H2 Zn finger 370..390 CDD:275368
C2H2 Zn finger 398..418 CDD:275368
C2H2 Zn finger 426..446 CDD:275368
C2H2 Zn finger 454..474 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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