DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and Zfp189

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001101400.1	Gene:	Zfp189 / 313219	RGDID:	1306510	Length:	608	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	90/332 - (27%)
Similarity:	145/332 - (43%)	Gaps:	81/332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 MASPPDCLNDPFGEVDE--YIVESPEEVLDHDSDAHHDLDEDNYIDSVEDVDAL----QDMAEVA 152
            ||||    :.|....:|  |:..:|..:       :.|:..|:| ..:..:|.|    .:...|.
  Rat     1 MASP----SPPLESKEEWGYLDAAPRSL-------YKDVVMDSY-GKLVSLDVLNRNEDEEPTVK 53

  Fly   153 EEDSQDVES---LISSVQKELESICNDDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLPES 214
            ||..:|:|.   :::.::.||:              .:|.....|
  Rat    54 EEIEKDIEPQGIIVTRIKSELD--------------QDPMGSETF-------------------- 84

  Fly   215 KSAAGRSTKPATTKPKRKKQYVTWK----NMTEEQII------ERKRLQRKREC-VCEQCGRQFT 268
             ...||..|        ::....|:    ::||||.:      .|||...:.:| .||:||::|.
  Rat    85 -ELVGRLDK--------QRGIFLWEIPRDSLTEEQKMFRGHTNVRKRPNSEEKCHKCEECGKRFV 140

  Fly   269 DQSNFKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIH 333
            .:::|..|...|||.|.|.|.:|||.|.....:..||| ||.||:||:|.:|.|:|..|:|.:.|
  Rat   141 RKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQR-IHTGERPYECNYCGKTFSVSSTLIRH 204

  Fly   334 ERTHTNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRS-----K 393
            :|.||..:||.|:.|.:.|.......:|:.||||.:...|:.|.::|...:||..|.|:     .
  Rat   205 QRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKP 269

  Fly   394 FHTAKAK 400
            :|..|.|
  Rat   270 YHCTKCK 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..297	CDD:290200	12/24 (50%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
		C2H2 Zn finger	345..365	CDD:275368	4/19 (21%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
Zfp189	NP_001101400.1	KRAB_A-box	<10..39	CDD:143639	6/36 (17%)
		COG5048	116..506	CDD:227381	60/162 (37%)
		C2H2 Zn finger	132..152	CDD:275368	7/19 (37%)
		zf-H2C2_2	144..169	CDD:290200	12/24 (50%)
		C2H2 Zn finger	160..180	CDD:275368	8/20 (40%)
		zf-H2C2_2	175..196	CDD:290200	12/21 (57%)
		C2H2 Zn finger	188..208	CDD:275368	8/19 (42%)
		zf-H2C2_2	201..225	CDD:290200	9/23 (39%)
		C2H2 Zn finger	216..236	CDD:275368	4/19 (21%)
		zf-H2C2_2	228..252	CDD:290200	7/23 (30%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..281	CDD:290200	7/21 (33%)
		C2H2 Zn finger	272..292	CDD:275368	2/5 (40%)
		zf-H2C2_2	285..307	CDD:290200
		C2H2 Zn finger	300..320	CDD:275368
		zf-H2C2_2	312..337	CDD:290200
		C2H2 Zn finger	328..348	CDD:275368
		zf-H2C2_2	341..365	CDD:290200
		C2H2 Zn finger	356..376	CDD:275368
		zf-H2C2_2	368..393	CDD:290200
		C2H2 Zn finger	384..404	CDD:275368
		C2H2 Zn finger	440..460	CDD:275368
		zf-H2C2_2	452..477	CDD:290200
		C2H2 Zn finger	468..488	CDD:275368
		zf-H2C2_2	481..505	CDD:290200
		C2H2 Zn finger	496..516	CDD:275368
		zf-H2C2_2	508..533	CDD:290200
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	537..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000