DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZNF789

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_998768.2	Gene:	ZNF789 / 285989	HGNCID:	27801	Length:	425	Species:	Homo sapiens

Alignment Length:	260	Identity:	71/260 - (27%)
Similarity:	114/260 - (43%)	Gaps:	30/260 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 SQDVESLISSV--QKELESI------CNDDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLP 212
            |:|:||...||  |:..|.:      |.:..:|....:  |.:|       :||......|..|.
Human   106 SEDLESYKISVVMQESAEKLSEKLHKCKEFVDSCRLTF--PTSG-------DEYSRGFLQNLNLI 161

  Fly   213 ESKSAAGRSTKPATTKPKRKKQYVTWKNMTEEQII--ERKRLQRKRECVCEQCGRQFTDQSNFKL 275
            :.::        |.|:.|:.:.....|...:..::  ..:.|.|.:...|.:||:....::.|..
Human   162 QDQN--------AQTRWKQGRYDEDGKPFNQRSLLLGHERILTRAKSYECSECGKVIRRKAWFDQ 218

  Fly   276 HMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNA 340
            |...|.....|.|:.||:.|.....:|:|:: .|...|||.|..|.|.|......:.|:|.||..
Human   219 HQRIHFLENPFECKVCGQAFRQRSALTVHKQ-CHLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKE 282

  Fly   341 KPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAH--LRSKFHTAKAKTIG 403
            |||.|..|:|.|...|...||::||:|.:...|..|.::|.|::.|..|  :.||.:|.|....|
Human   283 KPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHKCLECGKAFGRHSTLLCHQQIHSKPNTHKCSECG 347

Fly 404 403
Human 348 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	272..297	CDD:290200	8/24 (33%)
		C2H2 Zn finger	288..309	CDD:275368	6/20 (30%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		C2H2 Zn finger	373..391	CDD:275368	6/19 (32%)
ZNF789	NP_998768.2	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<179..303	CDD:227381	36/124 (29%)
		C2H2 Zn finger	179..195	CDD:275368	1/15 (7%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	6/20 (30%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	271..296	CDD:290200	11/24 (46%)
		COG5048	<283..420	CDD:227381	24/65 (37%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		C2H2 Zn finger	343..363	CDD:275368	1/5 (20%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050