DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZNF547

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_775902.2	Gene:	ZNF547 / 284306	HGNCID:	26432	Length:	402	Species:	Homo sapiens

Alignment Length:	297	Identity:	83/297 - (27%)
Similarity:	123/297 - (41%)	Gaps:	54/297 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 HHDLDEDNYIDSVEDVDALQDMAE---VAEEDSQDVESLISSVQKELESICNDDSNSDNNDYMEP 188
            |...||:..::....|...|.||.   ::.:::|..|: .||:.|::..:...|..       .|
Human    54 HGAEDEEAPLEPGVSVGVSQVMAPKPCLSTQNTQPCET-CSSLLKDILRLAEHDGT-------HP 110

  Fly   189 QNGSYF---------NETINEYEVSSNPNTPLPESKSAAGRSTKPATTKPKR------------- 231
            :.|.|.         .|.|.|              |.:.|...:|...|..|
Human   111 EQGLYTCPAHLHQHQKEQIRE--------------KLSRGDGGRPTFVKNHRVHMAGKTFLCSEC 161

  Fly   232 KKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFY 296
            .|.:.....:::.|.|.    ..:|...|.:||..|.::|....|...|||.:.:.|.:|||.|.
Human   162 GKAFSHKHKLSDHQKIH----TGERTYKCSKCGILFMERSTLNRHQRTHTGERPYECNECGKAFL 222

  Fly   297 TDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRH 361
            ....:..|| .||.||:||:|..|.|.|..|:|.:.|:|.||..:||.|..|.|.||..|...||
Human   223 CKSHLVRHQ-TIHSGERPYECSECGKLFMWSSTLITHQRVHTGKRPYGCSECGKFFKCNSNLFRH 286

  Fly   362 ELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAK 398
            ..||||.|::.|:.|.:.|...:.|..|.|  .||.:
Human   287 YRIHTGKRSYGCSECGKFFMERSTLSRHQR--VHTGE 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	288..309	CDD:275368	7/20 (35%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..391	CDD:275368	5/17 (29%)
ZNF547	NP_775902.2	KRAB	11..66	CDD:214630	3/11 (27%)
		KRAB	11..50	CDD:279668
		COG5048	<156..314	CDD:227381	55/162 (34%)
		C2H2 Zn finger	158..178	CDD:275368	2/19 (11%)
		C2H2 Zn finger	186..206	CDD:275368	6/19 (32%)
		zf-H2C2_2	199..221	CDD:290200	8/21 (38%)
		C2H2 Zn finger	214..234	CDD:275368	7/20 (35%)
		zf-H2C2_2	226..249	CDD:290200	11/23 (48%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		C2H2 Zn finger	298..318	CDD:275368	6/21 (29%)
		zf-H2C2_2	311..334	CDD:290200	5/13 (38%)
		C2H2 Zn finger	326..346	CDD:275368
		zf-H2C2_2	339..363	CDD:290200
		C2H2 Zn finger	354..374	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050