DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZKSCAN5

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001305011.1	Gene:	ZKSCAN5 / 23660	HGNCID:	12867	Length:	839	Species:	Homo sapiens

Alignment Length:	410	Identity:	95/410 - (23%)
Similarity:	143/410 - (34%)	Gaps:	107/410 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QCRTCGSIIYNKMPKNLFHIENEKMLQDINLVTGTTLHNDPELPSSICACCTLDLNQAILFRERC 68
            :|..||.          |.::....:|...:.||       |.|.. |..|....||      |.
Human   347 RCSDCGK----------FFLQASNFIQHRRIHTG-------EKPFK-CGECGKSYNQ------RV 387

  Fly    69 ILTQKQLVHRRRSPEAKEPAEDVEEMASPPDCLNDPFGEVDEYIVESPEEVLDHDSDAHHDLDED 133
            .|||.|.||....|...:.......::|              ::|:            ||.:...
Human   388 HLTQHQRVHTGEKPYKCQVCGKAFRVSS--------------HLVQ------------HHSVHSG 426

  Fly   134 NYIDSVEDVDALQDMAEVAEEDSQDVESLISSVQKELESICND-DSNSDNNDYMEPQNGSYFNET 197
                                               |....||: ..|...:.::......:|.|.
Human   427 -----------------------------------ERPYGCNECGKNFGRHSHLIEHLKRHFREK 456

  Fly   198 INEYEVSSNPNTPLPESKSAAGRSTKPATTKPKRKKQYVTWKNMTEEQIIE-----RKRLQRKRE 257
            ........:.||.|...|..:..|........|      |.:|:::.|...     :.:|.||:.
Human   457 SQRCSDKRSKNTKLSVKKKISEYSEADMELSGK------TQRNVSQVQDFGEGCEFQGKLDRKQG 515

  Fly   258 C-VCEQCGRQFTDQSNFK----LHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDC 317
            . :.|..|:..:.:.|:.    :|....||.:...|.:|||.|.....:..||| ||.||||:.|
Human   516 IPMKEILGQPSSKRMNYSEVPYVHKKSSTGERPHKCNECGKSFIQSAHLIQHQR-IHTGEKPFRC 579

  Fly   318 RFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFACTICKQSFQR 382
            ..|.||::.......|:|.||..|||:|..|.|.|:..|...:|:.:|:|.|.|.|..|.:.|.|
Human   580 EECGKSYNQRVHLTQHQRVHTGEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCNECGKGFGR 644

  Fly   383 NTHLKAHL----RSKFHTAK 398
            .:||..||    |.|.|..:
Human   645 RSHLAGHLRLHSREKSHQCR 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	17/70 (24%)
		C2H2 Zn finger	260..280	CDD:275368	4/23 (17%)
		zf-H2C2_2	272..297	CDD:290200	9/28 (32%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..391	CDD:275368	8/21 (38%)
ZKSCAN5	NP_001305011.1	SCAN	46..155	CDD:128708
		SCAN	47..134	CDD:280241
		KRAB	222..257	CDD:279668
		COG5048	318..762	CDD:227381	95/410 (23%)
		C2H2 Zn finger	348..368	CDD:275368	5/29 (17%)
		zf-H2C2_2	360..385	CDD:290200	7/32 (22%)
		C2H2 Zn finger	376..396	CDD:275368	9/25 (36%)
		zf-H2C2_2	388..411	CDD:290200	7/22 (32%)
		C2H2 Zn finger	404..424	CDD:275368	4/45 (9%)
		C2H2 Zn finger	432..452	CDD:275368	3/19 (16%)
		zf-C2H2	549..571	CDD:278523	8/22 (36%)
		C2H2 Zn finger	551..571	CDD:275368	8/20 (40%)
		zf-H2C2_2	563..588	CDD:290200	13/25 (52%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..614	CDD:290200	10/22 (45%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	619..644	CDD:290200	8/24 (33%)
		C2H2 Zn finger	635..655	CDD:275368	8/19 (42%)
		C2H2 Zn finger	663..683	CDD:275368	0/2 (0%)
		zf-C2H2	717..739	CDD:278523
		C2H2 Zn finger	719..739	CDD:275368
		C2H2 Zn finger	747..795	CDD:275368
		COG5048	758..>823	CDD:227381
		zf-C2H2	773..795	CDD:278523
		zf-H2C2_2	787..811	CDD:290200
		C2H2 Zn finger	803..823	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050