DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZNF281

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001268222.1	Gene:	ZNF281 / 23528	HGNCID:	13075	Length:	895	Species:	Homo sapiens

Alignment Length:	314	Identity:	69/314 - (21%)
Similarity:	115/314 - (36%)	Gaps:	58/314 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PEEVLDHDSDAHHDL----------------DEDNYIDSVEDVDAL-QDMAEVAEEDSQDVESLI 163
            |||...|....||..                .|......::|:..| |.:.:...:..:||  |:
Human   135 PEEQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDV--LL 197

  Fly   164 SSVQKELESICNDDSNSDNNDYMEPQNGSYFNETINEYEVSSNPNTPLPESKSAAGRSTKPATTK 228
            ||..:          ..|::...||:..:...:.          ..|.|||:....:....|::|
Human   198 SSSSR----------TDDHHGTEEPKQDTNVKKA----------KRPKPESQGIKAKRKPSASSK 242

  Fly   229 PKRKKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGK 293
            |       :.....|..|:.    ..::..:|:.|...|....:.:.|:|.|||.:.|.|.||..
Human   243 P-------SLVGDGEGAILS----PSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSM 296

  Fly   294 RFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGR 358
            .|...:|:..|:: ||..|||:.|..|:..|........|:|||:..|||.|..|.:.|......
Human   297 GFIQKYLLQRHEK-IHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRL 360

  Fly   359 KRHELIHTGVRAFACTICKQSFQRNTHL-------KAHLRSKFHTAKAKTIGAE 405
            .:|......|.....|..:.....:|::       :.:..|.....|:|:|..|
Human   361 LKHRRTCGEVIVKGATSAEPGSSNHTNMGNLAVLSQGNTSSSRRKTKSKSIAIE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	272..297	CDD:290200	10/24 (42%)
		C2H2 Zn finger	288..309	CDD:275368	6/20 (30%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..365	CDD:275368	4/19 (21%)
		C2H2 Zn finger	373..391	CDD:275368	2/24 (8%)
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149		6/13 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..253		16/98 (16%)
		C2H2 Zn finger	263..283	CDD:275368	5/19 (26%)
		zf-H2C2_2	275..300	CDD:316026	10/24 (42%)
		C2H2 Zn finger	291..311	CDD:275368	6/20 (30%)
		zf-H2C2_2	304..328	CDD:316026	9/24 (38%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..356	CDD:316026	10/24 (42%)
		C2H2 Zn finger	347..366	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..427		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910