DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZSCAN25

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001337908.1	Gene:	ZSCAN25 / 221785	HGNCID:	21961	Length:	544	Species:	Homo sapiens

Alignment Length:	310	Identity:	82/310 - (26%)
Similarity:	116/310 - (37%)	Gaps:	59/310 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 EMASPPDCLNDPFGEVDEYIVESPEEVLDHDSDAHHDLDEDNYIDSVEDVDALQDMAEVAEEDSQ 157
            |...|.||...|.|...|...:.|:|.|.                     .||  :|..:|...:
Human   257 EYVEPQDCRVSPGGGSKEKEAKPPQEDLK---------------------GAL--VALTSERFGE 298

  Fly   158 DVESLISSVQ-KELESICNDDSNSDNND---YMEPQNGSYFNETINEYEVSSNPNTPLPESKSAA 218
                  :|:| ..|..:|..:.......   ...||:|:                .|||:.....
Human   299 ------ASLQGPGLGRVCEQEPGGPAGSAPGLPPPQHGA----------------IPLPDEVKTH 341

  Fly   219 GRSTKPATTKPKRKKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGN 283
            ....||... |:..|.:....|:...|     |...::...|.:||:.||.:.....|...|.|.
Human   342 SSFWKPFQC-PECGKGFSRSSNLVRHQ-----RTHEEKSYGCVECGKGFTLREYLMKHQRTHLGK 400

  Fly   284 KNFACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHC 348
            :.:.|.:|.|.|...|.:.:||| .|.|||||.|..|.|||.......:|.||||..|||:| .|
Human   401 RPYVCSECWKTFSQRHHLEVHQR-SHTGEKPYKCGDCWKSFSRRQHLQVHRRTHTGEKPYTC-EC 463

  Fly   349 DKCFKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAK 398
            .|.|...:....|...|||.:.:.|.:|.:.|.:...|..|.|  .||.:
Human   464 GKSFSRNANLAVHRRAHTGEKPYGCQVCGKRFSKGERLVRHQR--IHTGE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	7/24 (29%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		C2H2 Zn finger	373..391	CDD:275368	5/17 (29%)
ZSCAN25	NP_001337908.1	SCAN	38..136	CDD:322011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..189
		KRAB_A-box	231..>259	CDD:143639	1/1 (100%)
		COG5048	<324..532	CDD:227381	64/214 (30%)
		C2H2 Zn finger	350..370	CDD:275368	5/25 (20%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		C2H2 Zn finger	405..425	CDD:275368	8/20 (40%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..480	CDD:275368	5/19 (26%)
		C2H2 Zn finger	488..508	CDD:275368	6/21 (29%)
		C2H2 Zn finger	516..535	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960