DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18764 and ZNF460

DIOPT Version :9

Sequence 1:NP_652712.2 Gene:CG18764 / 59239 FlyBaseID:FBgn0042205 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_006626.3 Gene:ZNF460 / 10794 HGNCID:21628 Length:562 Species:Homo sapiens


Alignment Length:363 Identity:103/363 - (28%)
Similarity:152/363 - (41%) Gaps:51/363 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LDLNQAILFRERCILTQKQLVHRRRS--PEAKEPAEDVEEMASPPDCLNDPFGEVDEYIVESPEE 118
            ||:.|..|:.|..:.|...||....|  ||..||.         |..|            ..|||
Human    30 LDVTQRALYVEVMLETCGLLVALGDSTKPETVEPI---------PSHL------------ALPEE 73

  Fly   119 VLDHDSDAHHDLDEDNYIDSVEDVDALQDMAEV-----AEEDSQDVESLISSVQKEL---ESIC- 174
            |...:..| ..:...:|:....|.|...:|.|.     .:..|:.:...:|...:.|   :.|| 
Human    74 VSLQEQLA-QGVPRYSYLGQAMDQDGPSEMQEYFLRPGTDPQSEKLHGKMSLEHEGLATADGICS 137

  Fly   175 ----NDDSNSD---NNDYMEPQNGSYFNETINEY--EVSSNPNTPLPESKSAAGRSTKPATTKPK 230
                |..|..|   ..|...|...|..:|..|.|  |...|.|..|.:.:....| .||... |:
Human   138 MMIQNQVSPEDALYGFDSYGPVTDSLIHEGENSYKFEEMFNENCFLVQHEQILPR-VKPYDC-PE 200

  Fly   231 RKKQYVTWKNMTEEQIIERKRLQRKRECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRF 295
            ..|.:...|::.:..||.......|    |.:||:.|..:|:...|...|.|:|.|.|.:||:.|
Human   201 CGKAFGKSKHLLQHHIIHTGEKPYK----CLECGKDFNRRSHLTRHQRTHNGDKPFVCSECGRTF 261

  Fly   296 YTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKR 360
            .....:|.||| :|.||||:.|..|.|:|...:..::|.::|...||::|..|.|.|..::...:
Human   262 NRGSHLTRHQR-VHSGEKPFVCNECGKAFTYRSNFVLHNKSHNEKKPFACSECGKGFYESTALIQ 325

  Fly   361 HELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAK 398
            |.:||||.|.|.|..|.::|...:|||.|  .:.||.:
Human   326 HFIIHTGERPFKCLECGKAFNCRSHLKQH--ERIHTGE 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18764NP_652712.2 zf-AD 4..75 CDD:214871 6/18 (33%)
C2H2 Zn finger 260..280 CDD:275368 6/19 (32%)
zf-H2C2_2 272..297 CDD:290200 9/24 (38%)
C2H2 Zn finger 288..309 CDD:275368 8/20 (40%)
C2H2 Zn finger 317..337 CDD:275368 5/19 (26%)
C2H2 Zn finger 345..365 CDD:275368 5/19 (26%)
C2H2 Zn finger 373..391 CDD:275368 7/17 (41%)
ZNF460NP_006626.3 KRAB 12..53 CDD:307490 8/22 (36%)
C2H2 Zn finger 198..218 CDD:275368 4/20 (20%)
COG5048 222..552 CDD:227381 52/147 (35%)
C2H2 Zn finger 226..246 CDD:275368 6/19 (32%)
C2H2 Zn finger 254..274 CDD:275368 8/20 (40%)
C2H2 Zn finger 282..302 CDD:275368 5/19 (26%)
C2H2 Zn finger 310..330 CDD:275368 5/19 (26%)
C2H2 Zn finger 338..358 CDD:275368 7/21 (33%)
C2H2 Zn finger 366..386 CDD:275368
C2H2 Zn finger 394..414 CDD:275368
C2H2 Zn finger 422..442 CDD:275368
C2H2 Zn finger 450..470 CDD:275368
C2H2 Zn finger 478..498 CDD:275368
C2H2 Zn finger 506..526 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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