DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18764 and ZNF274

DIOPT Version :10

Sequence 1:NP_652712.2 Gene:CG18764 / 59239 FlyBaseID:FBgn0042205 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_598009.1 Gene:ZNF274 / 10782 HGNCID:13068 Length:653 Species:Homo sapiens


Alignment Length:439 Identity:115/439 - (26%)
Similarity:190/439 - (43%) Gaps:75/439 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 HIENEKMLQDINLVTGTTLHNDPEL-----PSSICACCTLDLNQAILFRERCILTQKQLVHRRRS 81
            |.||  ..:.:.||.|.|..::.|:     |:....||.....|....:|...:....::     
Human   225 HPEN--CQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVL----- 282

  Fly    82 PEAKEPAEDV------EE--MASPP------DCLNDPFGEVDEYIVESPEEVLDHDSDA-HHDLD 131
            ||.....:||      ||  :..|.      |.:.:.||.:   :....|..|::...| :.|:.
Human   283 PEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHL---VSVGWETTLENKELAPNSDIP 344

  Fly   132 EDNYIDSVEDVDALQD--MAEVAEEDSQ-DVESLISSVQKELESICNDD-SNSDNNDYMEPQNGS 192
            |:....|::..::.:|  ::...|:..| .|:.:..:|.|::||....| ....:.|..|.|..|
Human   345 EEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANS 409

  Fly   193 YFNETINEYEVSSNPNTPLPESKSAAG---------RSTKPATTKPKRKKQYVTWKNMTEEQIIE 248
            ...:| |:..:....|   |||::.:|         ....|.....||..|..:.|:.:..:|.:
Human   410 GALDT-NQVSLQKIDN---PESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQ 470

  Fly   249 --------------RKRLQRKRE-------------CVCEQCGRQFTDQSNFKLHMLRHTGNKNF 286
                          ||...|..:             |.|.:||:.|.:...|.:|...|||.:.:
Human   471 KSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPY 535

  Fly   287 ACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKC 351
            .||.|||.|.....:|.||| :|.||:|::|:.|.::|::.:....|.||||.||||.|..|.|.
Human   536 VCQDCGKGFVQSSSLTQHQR-VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKA 599

  Fly   352 FKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAKAK 400
            |:.:|...||:..|||.|.:||..|.::|.:::||..|.|:...|.:.|
Human   600 FRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKK 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18764NP_652712.2 zf-AD 4..75 CDD:214871 13/57 (23%)
C2H2 Zn finger 260..280 CDD:275368 6/19 (32%)
zf-H2C2_2 272..297 CDD:463886 11/24 (46%)
C2H2 Zn finger 288..309 CDD:275368 10/20 (50%)
C2H2 Zn finger 317..337 CDD:275368 5/19 (26%)
zf-H2C2_2 333..354 CDD:463886 13/20 (65%)
C2H2 Zn finger 345..365 CDD:275368 7/19 (37%)
C2H2 Zn finger 373..391 CDD:275368 6/17 (35%)
ZNF274NP_598009.1 KRAB 14..73 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..159
SCAN 157..245 CDD:460417 7/21 (33%)
KRAB 286..327 CDD:460171 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..359 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 6/25 (24%)
COG5048 <389..644 CDD:227381 76/259 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..485 5/36 (14%)
C2H2 Zn finger 481..501 CDD:275368 3/19 (16%)
C2H2 Zn finger 509..529 CDD:275368 6/19 (32%)
C2H2 Zn finger 537..557 CDD:275368 10/20 (50%)
C2H2 Zn finger 565..585 CDD:275368 5/19 (26%)
zf-C2H2 591..613 CDD:395048 8/21 (38%)
C2H2 Zn finger 593..613 CDD:275368 7/19 (37%)
zf-H2C2_2 605..630 CDD:463886 10/24 (42%)
C2H2 Zn finger 621..641 CDD:275368 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..653 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.