DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18764 and ZNF274

DIOPT Version :9

Sequence 1:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_598009.1	Gene:	ZNF274 / 10782	HGNCID:	13068	Length:	653	Species:	Homo sapiens

Alignment Length:	439	Identity:	115/439 - (26%)
Similarity:	190/439 - (43%)	Gaps:	75/439 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HIENEKMLQDINLVTGTTLHNDPEL-----PSSICACCTLDLNQAILFRERCILTQKQLVHRRRS 81
            |.||  ..:.:.||.|.|..::.|:     |:....||.....|....:|...:....::
Human   225 HPEN--CQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVL----- 282

  Fly    82 PEAKEPAEDV------EE--MASPP------DCLNDPFGEVDEYIVESPEEVLDHDSDA-HHDLD 131
            ||.....:||      ||  :..|.      |.:.:.||.:   :....|..|::...| :.|:.
Human   283 PEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHL---VSVGWETTLENKELAPNSDIP 344

  Fly   132 EDNYIDSVEDVDALQD--MAEVAEEDSQ-DVESLISSVQKELESICNDD-SNSDNNDYMEPQNGS 192
            |:....|::..::.:|  ::...|:..| .|:.:..:|.|::||....| ....:.|..|.|..|
Human   345 EEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANS 409

  Fly   193 YFNETINEYEVSSNPNTPLPESKSAAG---------RSTKPATTKPKRKKQYVTWKNMTEEQIIE 248
            ...:| |:..:....|   |||::.:|         ....|.....||..|..:.|:.:..:|.:
Human   410 GALDT-NQVSLQKIDN---PESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQ 470

  Fly   249 --------------RKRLQRKRE-------------CVCEQCGRQFTDQSNFKLHMLRHTGNKNF 286
                          ||...|..:             |.|.:||:.|.:...|.:|...|||.:.:
Human   471 KSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPY 535

  Fly   287 ACQQCGKRFYTDHLMTLHQRIIHQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKC 351
            .||.|||.|.....:|.||| :|.||:|::|:.|.::|::.:....|.||||.||||.|..|.|.
Human   536 VCQDCGKGFVQSSSLTQHQR-VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKA 599

  Fly   352 FKSASGRKRHELIHTGVRAFACTICKQSFQRNTHLKAHLRSKFHTAKAK 400
            |:.:|...||:..|||.|.:||..|.::|.:::||..|.|:...|.:.|
Human   600 FRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871	13/57 (23%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	11/24 (46%)
		C2H2 Zn finger	288..309	CDD:275368	10/20 (50%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..159
		SCAN	157..269	CDD:128708	12/45 (27%)
		SCAN	157..245	CDD:280241	7/21 (33%)
		KRAB	287..>327	CDD:214630	8/42 (19%)
		KRAB	287..326	CDD:279668	8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..359		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414		6/25 (24%)
		COG5048	<389..644	CDD:227381	76/259 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..485		5/36 (14%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..546	CDD:290200	11/24 (46%)
		C2H2 Zn finger	537..557	CDD:275368	10/20 (50%)
		zf-H2C2_2	549..573	CDD:290200	10/24 (42%)
		zf-C2H2	563..585	CDD:278523	5/21 (24%)
		C2H2 Zn finger	565..585	CDD:275368	5/19 (26%)
		zf-C2H2	591..613	CDD:278523	8/21 (38%)
		C2H2 Zn finger	593..613	CDD:275368	7/19 (37%)
		zf-H2C2_2	605..630	CDD:290200	10/24 (42%)
		C2H2 Zn finger	621..641	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..653		6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	1	0.950	-	0	Normalized mean entropy	S5197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910