DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17234 and MASP1

DIOPT Version :9

Sequence 1:	NP_722785.1	Gene:	CG17234 / 59225	FlyBaseID:	FBgn0042187	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	271	Identity:	72/271 - (26%)
Similarity:	117/271 - (43%)	Gaps:	59/271 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QRIIGG---EPIGIEQVPWQVSL-----------QYFGDHVCGGSIYSENIIVTAAHCFFDEEGN 75
            :|||||   || |:  .|||..:           ::||    .|::.|.:.|:||||....:..:
Human   455 KRIIGGRNAEP-GL--FPWQALIVVEDTSRVPNDKWFG----SGALLSASWILTAAHVLRSQRRD 512

  Fly    76 R----LDDQGYQVRAG-SALTDSNGTLVDVAA-LIIHEEYAFDLNINDIAIVRLSTPLEFTSKVQ 134
            .    :..:...|..| ..:.|.:|.:...|| :::|.::......:|||:|:|..|:.....|.
Human   513 TTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVM 577

  Fly   135 PIPLAK---TNPYPRSIALVSGWGVS-------YILNDSTNLYPTHLQGLALHIKSIFSCRL--- 186
            |:.|.:   ..|.|..:.||:|||:|       .|::..|......||.:.|.:.....|:.
Human   578 PVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYE 642

  Fly   187 -------FDPSLLCAGTY--GRTACHGDSGGPLVVNKQL------VGVVSW-GRKGCVSS---AF 232
                   ...::.|||.|  |:..|.|||||..|:...|      .|:||| |.:.|.|.   ..
Human   643 SRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGV 707

  Fly   233 FVSVPYFREWI 243
            :..|..:.:|:
Human   708 YTKVSNYVDWV 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17234	NP_722785.1	Tryp_SPc	26..243	CDD:214473	71/268 (26%)
CG17234	NP_722785.1	Tryp_SPc	27..243	CDD:238113	70/267 (26%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056
		Tryp_SPc	456..718	CDD:214473	71/268 (26%)
		Tryp_SPc	457..718	CDD:238113	70/267 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910