DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17234 and KLKB1

DIOPT Version :9

Sequence 1:	NP_722785.1	Gene:	CG17234 / 59225	FlyBaseID:	FBgn0042187	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	255	Identity:	81/255 - (31%)
Similarity:	121/255 - (47%)	Gaps:	48/255 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RIIGGEPIGIEQVPWQVSLQY---FGDHVCGGSIYSENIIVTAAHCFFDEEGNRLDDQGYQVRAG 87
            ||:||......:.|||||||.   ...|:||||:.....::||||||   :|..|.|. :::.:|
Human   401 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF---DGLPLQDV-WRIYSG 461

  Fly    88 ----SALTDSNGTLVDVAALIIHEEYAFDLNINDIAIVRLSTPLEFTSKVQPIPLAK-------- 140
                |.:| .:.....:..:|||:.|......:|||:::|..||.:|...:||.|..
Human   462 ILNLSDIT-KDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIY 525

  Fly   141 TNPYPRSIALVSGWGVSYILNDSTNLYPTHLQGLALHIKSIFSCR------LFDPSLLCAGTY-- 197
            ||.:      |:|||.|....:..|:    ||.:.:.:.:...|:      .....::||| |
Human   526 TNCW------VTGWGFSKEKGEIQNI----LQKVNIPLVTNEECQKRYQDYKITQRMVCAG-YKE 579

  Fly   198 -GRTACHGDSGGPLVVNK----QLVGVVSWGRKGCV---SSAFFVSVPYFREWILNAIAS 249
             |:.||.||||||||...    :|||:.||| :||.   ....:..|..:.:|||....|
Human   580 GGKDACKGDSGGPLVCKHNGMWRLVGITSWG-EGCARREQPGVYTKVAEYMDWILEKTQS 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17234	NP_722785.1	Tryp_SPc	26..243	CDD:214473	77/247 (31%)
CG17234	NP_722785.1	Tryp_SPc	27..243	CDD:238113	76/246 (31%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	77/247 (31%)
		Tryp_SPc	402..632	CDD:238113	76/246 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910