DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17234 and PRSS53

DIOPT Version :9

Sequence 1:	NP_722785.1	Gene:	CG17234 / 59225	FlyBaseID:	FBgn0042187	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	252	Identity:	63/252 - (25%)
Similarity:	94/252 - (37%)	Gaps:	66/252 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PWQVSLQYFGDHVCGGSIYSENIIVTAAHCFFDEEGNRLDDQGYQVRAGSALTDS---NGTLVDV 100
            |||.|::..|.|:|.||:.::..::||||||  |:....:...:.|..||...:.   ....|.|
Human    49 PWQASVRRQGAHICSGSLVADTWVLTAAHCF--EKAAATELNSWSVVLGSLQREGLSPGAEEVGV 111

  Fly   101 AALIIHEEYAFDLNINDIAIVRLSTPLEFTSKVQPIPLAKTNPYPRSIALVSGWG---------- 155
            |||.:...|......:|:|:::|:.|...|....|.| |...|:..| ...:||.
Human   112 AALQLPRAYNHYSQGSDLALLQLAHPTTHTPLCLPQP-AHRFPFGAS-CWATGWDQDTSDGKCWP 174

  Fly   156 -----------------------VSYILNDSTNLYPT--------HLQGLALHIKSIFSCRLF-- 187
                                   .|.:|..|..|.|.        .|:.|.|.:.|..:|...
Human   175 RLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYN 239

  Fly   188 -----------DPSLLCAGTYG--RTACHGDSGGPLVVNKQLVGVVSWGRKGCVSSA 231
                       .|.:||.|...  :..|.||||||::.   |.....|.:.|.:|.|
Human   240 QLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLC---LEPDGHWVQAGIISFA 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17234	NP_722785.1	Tryp_SPc	26..243	CDD:214473	63/252 (25%)
CG17234	NP_722785.1	Tryp_SPc	27..243	CDD:238113	63/252 (25%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	63/252 (25%)
		Tryp_SPc	43..314	CDD:214473	63/252 (25%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030