DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17234 and TMPRSS6

DIOPT Version :9

Sequence 1:NP_722785.1 Gene:CG17234 / 59225 FlyBaseID:FBgn0042187 Length:251 Species:Drosophila melanogaster
Sequence 2:NP_001275929.1 Gene:TMPRSS6 / 164656 HGNCID:16517 Length:824 Species:Homo sapiens


Alignment Length:245 Identity:70/245 - (28%)
Similarity:116/245 - (47%) Gaps:42/245 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RIIGGEPIGIEQVPWQVSLQYFGDHVCGGSIYSENIIVTAAHCFFDEEGNRLDDQGYQVRAGSAL 90
            ||:||......:.|||.|||..|.|:|||::.::..::||||||  :|.:......:.|..|...
Human   567 RIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCF--QEDSMASTVLWTVFLGKVW 629

  Fly    91 TDSN--GTL-VDVAALIIHEEYAFDLNINDIAIVRLSTPLEFTSKVQPIPLAKTNPY--PRSIAL 150
            .:|.  |.: ..|:.|::|..:..|.:..|:|:::|..|:..::.|:|:.|...:.:  |.....
Human   630 QNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCW 694

  Fly   151 VSGWGV---SYILNDSTNLY---------------PTHLQGLALHI------KSIFSCRLFDPSL 191
            ::|||.   ..:..|:..|:               ...||.:.:.:      ..::..:: .|.:
Human   695 ITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYRYQV-TPRM 758

  Fly   192 LCAGTY---GRTACHGDSGGPLVVNKQ-----LVGVVSWGRKGCVSSAFF 233
            |||| |   .:.||.||||||||....     |.|:|||| .||....:|
Human   759 LCAG-YRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWG-LGCGRPNYF 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17234NP_722785.1 Tryp_SPc 26..243 CDD:214473 70/245 (29%)
Tryp_SPc 27..243 CDD:238113 69/244 (28%)
TMPRSS6NP_001275929.1 SEA 77..177 CDD:307516
CUB 326..440 CDD:238001
LDLa 450..480 CDD:238060
LDLa 486..516 CDD:238060
Ldl_recept_a 520..557 CDD:278486
Tryp_SPc 568..822 CDD:238113 69/244 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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