DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCU and MCU

DIOPT Version :9

Sequence 1:	NP_001246647.1	Gene:	MCU / 59223	FlyBaseID:	FBgn0042185	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_612366.1	Gene:	MCU / 90550	HGNCID:	23526	Length:	351	Species:	Homo sapiens

Alignment Length:	326	Identity:	146/326 - (44%)
Similarity:	215/326 - (65%)	Gaps:	9/326 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 GTNPCGAQEFKESNSFAGTQVHSLKKRIKNRKIKKKLILNRKKKKKKTC-----NEDIYVEYVNG 172
            |...|||   ..:..|.|..|...:::..:|.:.:: |.:.:......|     ::|:.|.|.||
Human    22 GAGGCGA---LTAGCFPGLGVSRHRQQQHHRTVHQR-IASWQNLGAVYCSTVVPSDDVTVVYQNG 82

  Fly   173 MPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVRIASSCTIESLLDD 237
            :|.::||||||.|.|||.|||||.:||..|..|:.|||||||.|:.:..|||:|:|..|:.||.|
Human    83 LPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLD 147

  Fly   238 SFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEKSNQLAKELETLRY 302
            .|.:.||:.|..|.|||||.::.|:...:.||:.::.|||....:.::||.|..:|.:.||.|:.
Human   148 DFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKE 212

  Fly   303 ELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIMEPVTYFVTYGTTMA 367
            :|.|||:.::|:|:||.:||..:.|.||..|:.||||||||||||||||||||||||:|||:.||
Human   213 QLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMA 277

  Fly   368 MYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEYNLRRINDPLNMQL 432
            ||||:.:|::||:..:.::|::.|..::.|||.:||:|.||:||...|:.|.:|:|:.|||.:.|
Human   278 MYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHL 342

  Fly   433 P 433
            |
Human   343 P 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCU	NP_001246647.1	MCU	208..410	CDD:282525	100/201 (50%)
MCU	NP_612366.1	N-terminal MCU domain. /evidence=ECO:0000269\|PubMed:26341627	75..165		49/89 (55%)
		MCU	118..320	CDD:398382	99/201 (49%)
		Outer juxtamembrane helix (OJMH). /evidence=ECO:0000250\|UniProtKB:Q21121	216..234		8/17 (47%)
		DXXE. /evidence=ECO:0000250\|UniProtKB:Q21121	261..264		2/2 (100%)
		Inner juxtamembrane helix (IJMH). /evidence=ECO:0000250\|UniProtKB:Q21121	283..292		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158064
Domainoid	1	1.000	220	1.000	Domainoid score	I2644
eggNOG	1	0.900	-	-		E1_KOG2966
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9916
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2797
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48647
OrthoDB	1	1.010	-	-		D1076768at2759
OrthoFinder	1	1.000	-	-		FOG0004164
OrthoInspector	1	1.000	-	-		oto90803
orthoMCL	1	0.900	-	-		OOG6_105346
Panther	1	1.100	-	-	LDO	PTHR13462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1219
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770