DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCU and Mcub

DIOPT Version :9

Sequence 1:	NP_001246647.1	Gene:	MCU / 59223	FlyBaseID:	FBgn0042185	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_006233342.1	Gene:	Mcub / 295462	RGDID:	1305326	Length:	335	Species:	Rattus norvegicus

Alignment Length:	273	Identity:	97/273 - (35%)
Similarity:	166/273 - (60%)	Gaps:	0/273 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 TCNEDIYVEYVNGMPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVR 224
            |..::|.|.|.:|:|.:|:.||||.|.|||.:||:...||..|..|:.||:||..||::...|..
  Rat    54 TSQDEITVNYRHGLPFVTLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIKTAAMVTADGSE 118

  Fly   225 IASSCTIESLLDDSFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEK 289
            |.::..:::||...|.:.|||...|:...::::.:.|...::.:.:.::.:|:...::.|.|..:
  Rat   119 IPAATLMDTLLMKDFKLVINNLPYDIRRHEKERPSEEHRTQLENTKCLVHRLFTILHLEEVQKRR 183

  Fly   290 SNQLAKELETLRYELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIME 354
            ...|..:::.|:.:|.|||:.|..:..::..:|:.:.|.||.|:|||.|.||.||||.|||||||
  Rat   184 ERHLMAKIDHLQEQLRPLEQVKAGIEARSEAKTSSLLWAGLALLSVQGGALAWLTWWVYSWDIME 248

  Fly   355 PVTYFVTYGTTMAMYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEY 419
            |||:|:|:..:|..:||:.||::.|..|.:::|:|....:|.:::..||||.||:||...||...
  Rat   249 PVTFFLTFANSMVFFAYFIVTRQNYTYESLRSRQFLQFFHRKSRRQCFDVERYNKLKEDLAEATE 313

  Fly   420 NLRRINDPLNMQL 432
            :|..:...|.::|
  Rat   314 SLENVRHSLCLRL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCU	NP_001246647.1	MCU	208..410	CDD:282525	69/201 (34%)
Mcub	XP_006233342.1	MCU	101..304	CDD:282525	69/202 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2966
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1076768at2759
OrthoFinder	1	1.000	-	-		FOG0004164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13462
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1219
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880