DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCU and Mcu

DIOPT Version :9

Sequence 1:	NP_001246647.1	Gene:	MCU / 59223	FlyBaseID:	FBgn0042185	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001099868.1	Gene:	Mcu / 294560	RGDID:	1589771	Length:	350	Species:	Rattus norvegicus

Alignment Length:	280	Identity:	138/280 - (49%)
Similarity:	199/280 - (71%)	Gaps:	0/280 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 NEDIYVEYVNGMPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVRIA 226
            ::|:.|.|.||:|.::||||||.|.|||.|||||.:||..|..|:.|||||||.|:.:..|||:|
  Rat    71 SDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVA 135

  Fly   227 SSCTIESLLDDSFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEKSN 291
            :|..|:.||.|.|.:.||:.|..|.|||||.::.|:.:.:.||:.::.|||....:.::||.|..
  Rat   136 ASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAETLNDVKTLVQQLYTTLCIEQHQLNKER 200

  Fly   292 QLAKELETLRYELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIMEPV 356
            :|.:.||.||.:|.|||:.::|:|:||.:||..:.|.||..|:.|||||||||||||||||||||
  Rat   201 ELVERLEDLRQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPV 265

  Fly   357 TYFVTYGTTMAMYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEYNL 421
            |||:|||:.||||||:.:|::||:..:.::|::.|..::.|||.:||:|.||:||...|:.|.:|
  Rat   266 TYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDL 330

  Fly   422 RRINDPLNMQLPSHLVRTQE 441
            :|:.|||.:.||...:..:|
  Rat   331 KRLRDPLQVHLPLRQIGEKE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCU	NP_001246647.1	MCU	208..410	CDD:282525	101/201 (50%)
Mcu	NP_001099868.1	MCU	117..319	CDD:398382	101/201 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352047
Domainoid	1	1.000	224	1.000	Domainoid score	I2475
eggNOG	1	0.900	-	-		E1_KOG2966
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9916
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2681
OMA	1	1.010	-	-		QHG48647
OrthoDB	1	1.010	-	-		D1076768at2759
OrthoFinder	1	1.000	-	-		FOG0004164
OrthoInspector	1	1.000	-	-		oto97904
orthoMCL	1	0.900	-	-		OOG6_105346
Panther	1	1.100	-	-	LDO	PTHR13462
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1219
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810